Association of Inherited Thrombophilia with Recurrent Pregnancy Loss in A Population of Lebanese Women: A Case Control Study

Recurrent pregnancy loss (RPL) complication is a challenge of reproductive medicine due to its often unknown etiology.A case-control study was carried out between June 2019 and April 2020 to examine the correlation between RPLand inherited thrombophilia (IT), namely mutations in factor V Leiden (FVL G1691A), prothrombin (FII G20210A),and methylenetetrahydrofolate reductase (MTHFR C677T). A total of 120 Lebanese women with RPL was studiedand compared, for the frequency of these mutations, to 100 healthy reproductive Lebanese women. The associationbetween the zygosity status of the three tested mutations, the existence of more than one prothrombotic single nucleotidepolymorphisms (SNPs), and the increased risk of RPL were examined using Chi-square or two-tailed fisher exacttest, and the student t test. The predictive factors of RPL were analyzed using a multiple logistic regression model.P<0.05 was considered to be statistically significant. Our results showed statistically significant higher frequenciesof FVL G1691A and FII G20210A mutations among the cases with RPL compared to the control group. Thus, RPL isassociated with FVL G1691A and FII G20210A mutations. These mutations seem to increase the risk of RPL in theLebanese women. Therefore, we suggest thrombophilia screening and adequate genetic counseling for women withRPL and at high-risk to plan for primary prevention, avoiding thromboembolic or obstetric accidents, and reducingthe associated morbidity and mortality among Lebanese women.