Association Study of Interleukin 23 Receptor (IL-23R) Polymorphisms with Inflammatory Bowel Disease (IBD) in Khuzestan Province of Iran

Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is a complex multifactorial disease for which the exact cause is not clear. In this study, the researcher aimed to evaluate interleukin 23 receptor (IL23R) gene polymorphisms in patients with inflammatory bowel disease.

In this case-control study, we evaluated 125 patients of the Iranian population (Khuzestan) with IBD, including 35 patients with CD, 90 patients with UC, and 125 healthy controls. The polymorphisms of C/A-97952 (rs10889677), and G/A-43045 (rs1004819) were genotyped, using ARMS-PCR and G/A-78790 (rs11209026) using RFLP-PCR methods in the studied population. The collected data were analyzed using SPSS software.

In this study, no significant association was observed between IL23R polymorphisms and IBD in this population, however the association between C/A-97952 AA genotype and penetrate to the tissue (P=0.048 OR=2.812 (1.23-6.44)), G/A-43045, AA genotype, and Ileocolic (P=0.031 OR=5 (1.071-31)). and G/A-43045 AA genotype and Pan Colitis (P=0.028 OR=4 (1.082-17.00)) in IBD were strengthened and emphasized.

The present study showed that there were no associations between IL23R polymorphisms, CD, and UC in the Khuzestan population. In addition, we found that C/A-97952 and G/A-43045 gene polymorphisms in IL-23R are related to special phenotypes. Further functional analysis with a larger sample size and other known IL-23 receptor genotypes is necessary to confirm our population's association with UC and CD.