Assessment of mean platelet volume in diabetes mellitus and its correlation with hba1c in normoglycemic, diabetic and prediabetic status

 Diabetes mellitus (DM) is a major global health issue in the modern era. Type 2 DM is the most common form and accounts for 90%. DM is identified to have a prothrombotic tendency, and the causative agent involved in this process might be the hyperactivity of the platelets. This study is intended to assess mean platelet volume in diabetes mellitus patients as well as the correlation between HbA1c and Mean Platelet Volume (MPV) in prediabetic, diabetic, and normoglycemic status.

 This was a prospective study conducted in the department of pathology, Hassan Institute of Medical Science, Hassan, India for a period of 3 months, from May 2022 to July 2022. The total sample size of this study was 600, which included 200 cases of diabetes, 200 patients with prediabetic status, and 200 subjects with normoglycemic levels. Diabetic, prediabetic, and normoglycemic status was confirmed by reviewing the medical records. Cases with abnormal hematocrit, abnormal platelet values, and chemotherapy patients were excluded from the study. Data was compiled and statistically analyzed using Microsoft Excel 2021. 

 The most common age group to have DM was 41 to 50 years, followed by 61 to 70 years. There is gender predilection in DM. The majority of people with diabetes have MPV between 8.01 to 10.00 fL. However, the majority of non-diabetics have MPV below eight fL.

 MPV is found to be higher in the people with diabetes when compared to prediabetics and non-diabetics. Also, HbA1c and MPV are positively correlated. Hence MPV and HbA1c can be used as markers of poor glycemic control and associated complications of diabetes.