Study of serum lipid profile in patients with oral submucous fibrosis and oral squamous cell carcinoma and their comparative analysis

The aim of this study was to evaluate serum lipid profile and compare their levels between the patients with oral submucous fibrosis (OSMF) and oral squamous cell carcinoma (OSCC).

This descriptive study was done in two groups of patients; OSMF and OSCC patients. There were forty-five participants in each group. Serum samples obtained from centrifugation of 12 hour fasting blood samples was analyzed by fully automated analyzer Beckman coulter AU-680 for estimation of the lipid levels (cholesterol, triglycerides (TGL), and high‑density lipids (HDL)) using colorimetric methods. Low‑density lipid (LDL) values were obtained by calculation.

The comparison of lipid profile between Oral Submucous Fibrosis and Oral Carcinoma cases shows statistically significant results for TC, HDL and LDL.

The change in lipid levels may have an early diagnostic or prognostic role in oral premalignant and malignant lesions.