The Importance of Other HPV in High-Grade CIN

 High-risk (HR) HPV infection is the major cause of cervical cancer, which is still one of the most common cancers among women. Based on some not-published results, it seems that some of the other HR HPVs might be as important as HPV 16, and 18 in developing high-grade CIN. This study was conducted to determine the relationship between Other HPV and high-grade CIN.

 In this prospective study from 2019 to 2022 (approved by the ethics committee), all women with positive HPV based on the COBAS method were invited to participate in the study (N=646). For all the patients, colposcopy was done, and then the liquid-based samples of women with Other HPV positives were reanalyzed by HPV typing.

 All the patients who were infected with HPV18 were involved in CIN1. On the other hand, 50% of patients who were infected with HPV18 were involved in CIN2. 50% of patients with HPV45 were involved in CIN2. There is also a significant relationship between HPV31 and CIN3.

Because in our study there was a significant relationship between CIN3 and HPV31; and CIN2 with HPV45, and in the COBAS method, HPV31 and HPV45 are only reported under the general title of Other HPV, because of the possibility of the importance of other HPV with high-grade neoplasias, it is recommended to analyze the other HPV with HPV typing. Further studies are needed to confirm our findings.