A Case of Multiple Myeloma with Extremely Rare Manifestation

Multiple myeloma (MM) is a neoplastic proliferation of immunoglobulin-producing plasma cells that have multiple presentations due to the infiltration of plasma cells in the bonemarrowand other organs. Commonmanifestations include anemia, bone pain, fatigue, and hypercalcemia. MMpresented with rectorrhagia is very rare.

A74-year-oldwomanwith a history of rectorrhagia episodes from about nine months ago presented with severe anemia, weakness, and lethargy. The findings of endoscopy and colonoscopy did not justify the patient’s manifestation, and finally, due to thrombocytopenia and anemia, a bone marrow biopsy was performed, and multiple myeloma was diagnosed.

Although GI bleeding in Multiple myeloma is a very rare manifestation, this diagnosis must be considered in the differential diagnosis of patients with unexplained and refractory GI bleeding.