Bactericidal effects of biosynthetic silver nanoparticles from a medicinal plant against multidrug-resistant Acinetobacter baumannii

Antimicrobial-resistant bacterial strains cause serious infections that can lead to increased mortality and morbidity rates, longer hospital stays, and financial losses. Finding new bactericidal agents against these bacterial is a critical concern. Silver nanoparticles (AgNPs) as an excellent antibacterial agent can play an effective role against these bacteria. Therefore, in the present study, biosynthesized AgNPs using leaf infusion of Dracocephalum kotschyi Boiss were used to assess their bactericidal effects against a multidrug-resistant (MDR) Acinetobacter baumannii (a gram-negative strain). Based on the obtained results, the maximum zone of inhibition was 16 mm and the minimal inhibitory concentration (MIC) of biosynthesized AgNPs was 15.62 μg/mL against MDR A. baumannii. Therefore, biosynthesized AgNPs as cost-effective, eco-friendly, and safe alternative material with excellent bactericidal effect can be used in different fields such medical and food industries.