Investigating Ovulation Induction Outcomes in Patients with Decreased Ovarian Reserve Treated with Double Stimulation during The Follicular and Luteal Phases Compared to The Conventional Antagonist Cycle: A Randomized Clinical Trial

It is difficult to obtain healthy oocytes in poor ovarian responders with conventional treatment methods.Thus, the need to investigate new methods is essential. This study aims to investigate ovulation induction outcomesin patients with decreased ovarian reserve (DOR) in two groups treated with double stimulation (DuoStim) during thefollicular and luteal phases in comparison with the antagonist cycle. This was a randomised clinical trial that enrolled the patients with reduced ovarian reserve. Thepatients referred for in vitro fertilisation (IVF) at Molud Infertility Clinic, Ali Ebn Abitalib (AS) Hospital, Zahedan, Iranfrom 2020 to 2021. Participants were randomly divided into two groups, those who underwent treatment with DuoStimduring the follicular and luteal phase (case group) and those who received the conventional antagonist cycle (control group). The mean number of metaphase II (MII) eggs was 7.7 ± 3.1 in the case group and 6.1 ± 3.9 in the controlgroup (P=0.063). The mean total number of retrieved eggs in the case group was 9.2 ± 3.7 and in the control group, itwas 6.9 ± 4.4 (P=0.023). The mean number of embryos obtained in the case group was 6.5 ± 3.9; in the control group,it was 4.7 ± 2.8 (P=0.016). The DuoStim method can effectively play a role in increasing the total number of retrieved eggs and embryos(registration number: IRCT20120817010617N8).