Measuring active matter levels in original and open forms of veterinary preparations containing oxytetracycline stored under varied storage conditions
This study aimed to evaluate the level of active matter in oxytetracycline stored under different conditions. Analyzing the active matter content of the drug was performed in its original packaging and in opened packages that were stored at room temperature, in the dark, and in the refrigerator for varying periods. Oxytetracycline was used for each preparation, and the active matter quantities were analyzed after 3, 6, and 9 months using HPLC. Additionally, considering the drug's life cycle, the opened packages were also analyzed at 24 and 48 hours. Results for the drug, which contained oxytetracycline (traditional) and was stored in a normal temperature room, were respectively: (6.14 ± 0.32, 6.50 ± 0.19), (5.58 ± 0.00, 6.38 ± 0.20), and (6.08 ± 0.10, 6.45 ± 0.32) ppm. Also, the results for the drug kept in the dark and a newly unwrapped drug were respectively: (6.29 ± 0.27, 6.37 ± 0.34), (5.30 ± 0.04, 6.30 ± 0.17), and (5.97 ± 0.13, 5.86 ± 0.06) ppm. Finally, the results for the drug kept in the refrigerator and a newly unwrapped drug were respectively: (7.55 ± 0.15, 7.48 ± 0.11), (5.36 ± 0.05, 5.81 ± 0.20), and (6.06 ± 0.36, 5.72 ± 0.07) ppm. Altogether, the results indicated that several external factors, such as heat, light, humidity, and oxygen, significantly impacted drug stability. Additionally, internal factors such as the internal reaction of the active ingredient, preservatives, and solvents influenced stability. Therefore, these various factors collectively affect the half-life of oxytetracycline.
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