Exploring the link between serum vitamin d and anti-müllerian hormone in polycystic ovary syndrome among reproductive-age women

Several studies were conducted earlier to find the association between serum Vitamin- D and Anti-Müllerian hormone (AMH) levels among women with Polycystic Ovary Syndrome (PCOS). The results from the existing studies were inconsistent. The objective of the present study was to find out the association between serum Vitamin D and AMH levels among women with PCOS.  

 A cross-sectional study was conducted in a Tertiary Care Teaching hospital in South India, 120 PCOS and 60 controls were included in the study. Age, Body Mass Index (BMI), Follicular Stimulating Hormone (FSH), Luteinizing hormone (LH), Estradiol (E2), Antral Follicular Count (AFC), Anti-Müllerian hormone (AMH), and 25-hydroxyvitamin D (25(OH)D) were analyzed among PCOS and control groups and comparisons were made.

 There was no significant difference (P =0.925) in the Vitamin D levels among PCOS and control groups. There was a positive correlation (r = 0.392; p = 0.002) between Vitamin D levels and AMH levels among PCOS group.

 The present study revealed that there was no significant difference between Vitamin D levels among PCOS and control groups. There was weak positive correlation between Vitamin D levels and AMH levels among PCOS group. Multilinear regression analysis with AMH as dependent variable and other parameters as dependent variables in PCOS group revealed that AMH levels were independently correlated with age but not with Vitamin D.