Dose Trifolium pratense L. Protect against Development of Fatty Streak in Coronary Arteries?
Author(s):
Asgari S. * , Moshtaghian J. , Naderi Ga , Fatahi Z. , Hosseini M. , Dashti Gr , Adibi Sh
Abstract:
Background
Phytoestrogens with a biological activity like estradiol are naturally found in many plants. Objective
This study was designed to investigate the effect of red clover (RC), a phytoestrogen-rich member of the legume family (Trifolium pratense L.) on the development of atherosclerosis in male hyperlipidemic rabbits. Method
Twenty rabbits were semi-randomly distributed into four groups of five each. Two groups received either normal diet or normal diet supplemented with RC. Two other groups received similar diets to both of which 1% cholesterol was added. Results
Dietary use of RC in hyperlipidemic rabbits significantly decreased C-reactive protein (CRP), triglyceride (TG), total cholesterol and LDL-cholesterol (LDL-C) whereas, HDL - cholesterol (HDL-C) was significantly increased in those animals (p<0.05). Fatty streak formation was also significantly lower in aorta and left and right coronary arteries in the same animals due to use of dietary RC supplementation. Conclusion
These findings suggest that dietary RC may reduce cardiovascular risk factors.Keywords:
Language:
Persian
Published:
Journal of Medicinal Plants, Volume:6 Issue: 22, 2007
Page:
39
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