Synthesis and Controlled Release of Biocompatible Prodrugs of β-Cyclodextrin Linked with PEG Co

Prodrugs of β-cyclodextrin (β-CD) conjugated with nonsteroidal anti-inflammatory drugs such as ibuprofen and indomethacin were prepared under mild conditions by two different routs. In the first procedure, β-CD was either reacted with ibuprofencarboxy chloride or treated with ibuprofen in the presence of dicyclohexylcarbodiimide (DCC). Also conjugated β-CD-indomethacin was prepared via reacting of β-CD with indometacin in the presence of DCC. In the second procedure, acid terminated poly (ethyleneglycol) (PEG, Mw = 600) was connected to the β-CD in the presence of DCC andthe resulted polymer reacted with ibuprofen. In the similar reactions, β-CD was linked toPEG then ibuprofen and indomethacin simultaneously reacted with resulted polymer. Thehydrolysis of drug-polymers was carried out in the aqueous buffer solutions in pH 1, 7.4,and 8 at 37oC. The quantity of hydrolyzed drugs was determined by using UV spectrophotometer.