Study of formulation variables on properties of glipizide mucoadhesive microspheres by factorial design
Author(s):
Abstract:
Background and the Purpose of the study:The purpose of the study was formulate and systemsystematic evaluation in-vitro and in-vivo behaviour of Glipizide mucoadhesive microspheres using 32 full factorial design.
Methods
Concentration of Polycarbophil and Sodium Alginate were selected as independent variables and the effects were checked on dependent variables like swelling index, mucoadhesion, drug entrapment efficiency and T75. In vivo studies were also performed to determine hypoglycemic activity of the mucoadhesive microspheres.Results
The best batch exhibited drug entrapment efficiency of 75%, swelling index of 1.8 and mucoadhesion was 100%. The drug release from the microspheres was also sustained for more than 9 hrs. Conclusion
The concentration of polycarbophil and sodium alginate had highly significant effects on dependent variables. In-vivo testing demonstrated a significant hypoglycemic effect of glipizide.Language:
English
Published:
DARU, Journal of Pharmaceutical Sciences, Volume:17 Issue: 4, winter2009
Pages:
236 to 244
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