Effects of Semelil (ANGIPARSTM) on diabetic peripheral neuropathy: A randomized, double-blind Placebo-controlled clinical trial
Author(s):
Abstract:
Background and the purpose of the study: Diabetic neuropathy is the most common diabetic complication that often is accompanied by significant morbidity, mortality and economic burden. The purpose of this study was evaluation of effect of Semelil (ANGIPARSTM), a new herbal drug for treatment of diabetic foot ulcers or diabetic peripheral neuropathy.
Methods
In this double blind clinical trial, 49 type 2 diabetes patients with different degrees of neuropathy were evaluated in two groups (ANGIPARSTM and placebo groups). All patients were assessed at the start and 12 weeks after treatment, with laboratory tests, United Kingdom screening test, Michigan neuropathy screening score, Michigan diabetic neuropathy score, vibration perception thresholds, nerve conduction study, monofilament test and visual analog scale.Results
Michigan diabetic neuropathy score was decreased notably in ANGIPARSTM group. In the nerve conduction study, appropriate meaningful changes were observed in the distal latency and amplitude in the motor Ulnar nerve in ANGIPARSTM group.Conclusion
The results showed limited evidence of efficacy of ANGIPARSTM in diabetic neuropathy treatment and more studies with a larger sample size and longer duration are required.Language:
English
Published:
DARU, Journal of Pharmaceutical Sciences, Volume:19 Issue: 1, 2011
Page:
65
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