Investigating the antioxidant effect of vitamin E in repressing of chromosomal damage induced by extremely low frequency electromagnetic field on bone marrow erythrocytes of male Balb/C mouse

Message:
Abstract:
Electricity is one of the advanced and technology keys. In recent decades using of generating devices of electromagnetic fields has led to placed humans exposed to electromagnetic fields. Vitamin E is one of the soluble antioxidant in fat that has an important role in lipoproteins، the biological membrane، nervous system، reproductive system and antioxidant chain the is placed against oxidative damage. In this research the antioxidant effects of vitamin E on the repressing of induced chromosomal damages by extremly low-frequency electromagnetic field on bone marrow erythrocytes of adult male Balb/C mouse has been studied.
Methods
In this experimental study، 31 adult male Balb/C mice were divided into 3 groups control، shamexposed and experimental groups. control group were kept in natural conditions، Mice in sham- exposed group were exposed to low electromagnetic field intensity 50Hz for 4 days، each day 4 hours and the mice in experimental group were injected intraperitoneally، vitamin E with dose of 200 Mg / Kg for 8 consecutive days، and the fifth day، these mice were exposed to electromagnetic fields intensity 50 Hz for 4 days، each day 4 hours. after completion of treatment، all mice were dissected and micronucleus test was evaluated in poly chromatic erythrocytes of bone marrow. Quantitative data obtained using of Spss software and ANOAA test at the level of pResult
Results showed that frequency of micronucleated polychromatic erythrocytes of experimental group (4. 545±0. 272) comparison with control group (5/307±0/4) and sham-exposed (11. 53±0. 634) group has been decreased meaningfully (pConclusion
Vitamin E caused the repressing of chromosomal damage in poly chromatic erythrocytes of bone marrow erythrocytes of adult male Balb/C mouse.
Language:
Persian
Published:
Journal of Plant and Biotechnology, Volume:5 Issue: 4, 2011
Page:
11
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