Journal of Medicinal and Chemical Sciences
Volume:3 Issue: 1, Jan 2020

Adsorption of Pb(II), Zn(II), Cu(II), and Cd(II) ions onto Mesembryanthemum activated carbon in a batch experimentby taking the consideration of adsorbent particle size, initial concentration, temperature, and pH was studied. Langmuir and Freundlich isotherm models were tested to fit the equilibrium data. Freundlich isotherm model gave a better fit to our experimental data than the Langmuir model. The adsorption capacity values were 66.67, 52.63, 45.45, and 40.00 mg/g for Pb(II), Zn(II), Cu(II), and Cd(II), respectively. The ideal pH for all metal ions adsorption was at pH 5. The obtained thermodynamic parameters suggested that the adsorption process was physical, spontaneous (ΔGo< 0), and endothermic (ΔHo> 0).

Developing a single analytical method for determination of individual drug from a multidrug composition is a very difficult task. The present work describes a simple, rapid, precise reverse phase chromatographic method that has been developed and validated for simultaneous estimation of multicomponent cream formulation containing Lignocaine HCl, Beclomethasone dipropionate and Phenylepherine HCl. The estimation was carried out on Hypersil BDS C18 (5 µm × 25 cm × 4.6 mm i.d.) column using a mixture of ammonium acetate buffer pH 5.0 and methanol in the ratio 60:40(v/v) as a mobile phase, at a flow rate of 1.0 ml/min and detection was performed at 222 nm. Three drugs Lignocaine HCl, Beclomethasone dipropionate and Phenylepherine HCl were eluted at the retention times of 3.3 min, 4.1 min and 11.49 min, respectively. The method was validated for accuracy, precision, linearity, specificity and sensitivity as per ICH guideline. The validated method is a rapid and cost effective and successfully applied to the commercially available pharmaceutical dosage form, yielding very good and reproducible result.

The main purpose of the present research article is the docking analysis of [11C]LY2795050 radiopharmaceutical with kappa (κ) and mu (µ) opioid receptors (KOR and MOR) and comparison of MOR-ligand and KOR-ligand complexes. In the first step, the title compound was optimized using B3LYP/6-31+G(d,p) basis set of theory at room temperature by Gaussian 03 software. Its reactivity and stability was done by frontier molecular orbitals (FMOs) theory. The molecular orbitals calculations indicate that this molecule prefers to react only with powerful nucleophile agents. The second step of this study is related to the docking analysis of the Ligand [11C]LY2795050 embedded in the active site of the kappa (κ) and mu (µ) opioid receptors. This work is done using Molegro Virtual Docker (MVD) software. The docking studies show that the possibility of the ligand-KOR complex formation is more than the ligand-MOR complex.

This work reports on synthesis of high yield (92%) of isosadeuterio-benzopinacol (benzopinacol-d20) via photo-reductive dimerization of benzophenone-d10. The latter compound was obtained using an improved method to achieve a material with high isotopic purity (> 99%). This material can be served for calibration of Mass spectrometric assays. In this study, it was also observed that benzophenone-d10 reacts faster than its natural abundance counterpart. However, elucidating the origin of this phenomenon will require additional work.

Phenanthro[9, 10-d]imidazole derivatives were synthesized with the combinations of phenanthroquinone and benzealdehyde derivatives in the presence of ammonium acetate. The microwave-assisted protocol was investigated under solvent-free condition for 2 min (400 w). The structure of all products was studied by IR and 1HNMR Spectroscopy. Excellent yields, short reaction times, simplicity of operation and easy separation are the advantages of this technique.

Drug creation based on synthesized azomethine derivatives of gossypol is of great interest with glycyrrhizic acid. Studies have shown that, in combination with glycyrrhizic acid, their solubility increases, these increasing the bioavailability of both the substance and its dosage form. We studied the degree of hydrolyzed megosin with MASGA, called megaferon and dosage form on its basis in the form of a 3% ointment with a pereeterifikat containing surfactant.

In this work, phthalocyanine and its OCH3 derivatives were investigated to see their photosensitization characteristics for producing singlet molecular oxygen, which is important in photodynamic therapy type-II. All structures were first optimized to achieve the minimized energy 3D models Subsequently, they were prepared for the photosensitization investigations. All the experiments were conducted based on the density functional theory calculations. The energy absorption and emission observed between the occupied and unoccupied molecular orbitals based on the required energy for excitation and the corresponding energy of emission. The results indicated that the OCH3 models could be expected to be safer than the original phthalocyanin by their required energy at longer wavelengths. The ratio of singlet molecular oxygen generation was found to be 1:1 for each of the OCH3 derivatives.

This article presents a review of the published scientific studies on the potential adverse effects of power frequency electromagnetic field (50-60 Hz) from domestic and occupational sources and electric transmission lines on female reproduction system and pregnancy outcome. In this review, publications in English were searched in the ISI Web of Knowledge, PubMed databases and GoogleScholar from January 2000 to December 2017 articles. For ascertaining the reliability of study, data were extracted independently and in duplicate by two investigators. According to some of the conducted studies, environmental exposure to power frequency EMF (electromagnetic field) exposure was found to adversely affect sex hormones, female genital system, embryonic development, pregnancy outcome and fetal and offspring development, while other studies reported no significant effect of power frequency EMF exposure on reproductive parameters and embryonic and fetal development. Overall, the results were not convergent and there was controversy regarding the findings. However, it can be concluded that a part of controversy can be attributed to differences in field strength and exposure time, the experiment condition in terms of in vivo and in vitro which had a significant impact on the observed results.

Novel developments in the synthetic techniques that facilitate rapid access to various functionalized heterocyclic compounds are essential in medicinal chemistry. They enable an expansion of the available drug-associated chemical space and enhance the efficiency of drug delivery. In addition, the creation of more robust synthetic techniques that can increase the drug yield can enhance the drug production rate. While researchers and manufacturers utilize established synthetic techniques during a program aimed at drug discovery, the innovation of heterocyclic synthesis processes that permit varied bond formation strategies is influencing the pharmaceutical industry in the most significant way. This review focuses on the utilization of some novel methods of activation of the C-H bonds, hydrogen borrowing catalysis, photoredox chemistry, regio- and stereo-selective synthesis, and multicomponent reactions for the functionalization and creation of heterocycles that aided in driving project delivery.

The aim of this study is to investigate naphtha Gasoline unit catalysts. In two-factor catalysts, platinum or palladium was used as the active metal on the base alumina chloride, zirconia, and zeolite. Considering the fact that refining and gasoline processes are expanding and refineries in Iran are required to produce cleaner fuels that meet environmental standards, investigating different kinds of light naphtha gasoline unit catalysts can greatly help to promote production of clean fuel and make production process more efficient. Light naphtha gasoline is normally conversion of normal pentane and normal hexane compounds to its branched compounds. Also Light naphtha its derivatives and it is done by chlorinated ammonia or zeolite catalysts in one or some fixed bed reactors.  Activity of two-factor catalysts strongly depends on acidic and metal sites. For example, in catalyst Pt./HY, which is a kind of zeolite catalyst for Gasoline Units, the optimal ratio of strong acidic sites to metal sites in n-heptane Gasoline is determined to be less than 6. In this work, various kinds of catalysts used in isomerization unit were identified and considered.