Journal of Research in Applied and Basic Medical Sciences
Volume:4 Issue: 1, Winter 2018

Factor XIII controls hemostatic, bleeding and thrombotic state. Inherited Factor XIII deficiency leads to an increased thrombotic tendency. Present study investigates the factor XIII gene Val34Leu mutation in the Iranian Turkish healthy females.

Totally 100 unrelated healthy Turkish females entered the study. 3-5 ml whole blood was collected in tube containing EDTA. Salting out method was used for isolation of genomic DNA from blood samples. Dde I based RFLP-PCR was performed to determine the factor XIII gene Val34Leu mutation in tested samples.

Our results showed that frequencies of G (Val) and T (Leu) alleles, and also, G/G (Val/Val), G/T (Val/Leu) and T/T (Leu/Leu) genotypes of factor XIII were 165(84.18%) and 31(15.82%),  and also, 67(68.37%), 31(31.63%) and 0(0%) in the tested group. Factor XIII gene Val34Leu genotypes showed an excellent fit to Hardy-Weinberg equilibrium in tested population (χ2 = 3.45 < 3.84, P-value (with degree of freedom=2) =0.177> 0.05). In this study, factor XIII G (Val) and T (Leu) allele frequencies were 0.84 and 0.16, respectively.

Our findings suggested that Factor XIII Val34Leu mutation has a very low prevalence in the tested population. These results from the Iranian Turkish females are the first official report and could be considered as control group for studies relating the prevalence of factor XIII gene Val34Leu mutation with human primary hemostatic, spontaneous bleeding and thrombotic disorders.

The immune system interference in Behcet's disease (BD) is typically cleared by Th1 as well as Th17 pathway - mediated inflammatory process.Among these, Interleukin-10 and 6, 8 as cytokines involved in inflammation have played a major role in autoimmune diseases. The aim of this study was to investigate the relationship between the severity of Behcet's disease with gene expression and methylation of IL-10, IL-6 and IL -8 genes.

Since this project had been investigated in a large study, we examined the association of IL10, IL6 and IL8 genes with the severity of BD. Accordingly, all analyses in this paper are limited to people with Behcet's. In this study, 26 patients are with severe BD and 21 with no severe BD. So, we examined Relationship between severity of BD disease and expression and methylation in these genes through appropriate statistical methods.

The mean expression rate of IL6 and IL8 genes in positive subjects with severe BD is higher than that of the ones with no severe BD; however, this is opposite in IL10. In addition, the methylation level of IL6 and IL10 genes in no severe BD subjects is greater than that of those with severe BD, however it is opposite in IL8.The difference between the expressions of IL10 in two groups and the difference between the methylation levels of IL8 and IL10 genes were reported to be significant (P <0.05).

In general, our results did not suggest any correlation between gene expressions of IL-10, Il-6, and IL-8. However, expression and methylation of these genes in the studied groups were difference in terms of disease severity.

The concentrations of urea, protein and macro-minerals and their interrelationships were investigated in lactating mares. Fifty-six samples including 17 colostrum and 39 whole milks were collected in 2011-2012 in Uremia, Iran. Milk parameters were evaluated by auto-analyzer using commercial kits, after separation of the milk casein in 0.1 normal HCl. The overall means for urea, protein, calcium (Ca), phosphorus (IP), magnesium (Mg), sodium (Na) and potassium (K) concentrations were 26.4 mg/dl, 4.66 g/dl, 43.2, 20.2, 7.33, 39.7, and 13.1 mmol/l, respectively. The concentrations of urea, Ca, IP and Na in whole milk were 24.4%, 2.8%, 14.3% and 9% greater than in colostrum and protein, and the Mg and K in colostrum’ were 505%, 91% and 9% greater than in whole milk of mares. Mean comparison between colostrum and whole milk parameters revealed significant differences (P< 0.01) in the concentrations of urea, protein and Mg. The highest concentrations of urea, Ca, IP and Na were found in whole milk and for protein, Mg and K in colostrum. With the exception of the differences (P<0.05) in colostrum Ca concentrations between 5, 9 and 10 year olds, no significant differences were observed among the six age groups in milk and colostrum parameters. There were significant correlations between urea/protein (r=-.19, P<0.01), urea/Ca (r=.37, P<0.01), urea/IP (r=-.35, P<0.01), urea/Mg (r=-0.32, P<0.01), Ca/IP (r=0.47, P<0.01), Na/K (r=-0.49, P<0.01) and protein/Mg (r=-0.72, P<0.01), of which the greatest and strongest correlations were seen in urea and protein/magnesium, respectively. It is concluded that the concentrations of protein and Mg in colostrum of mares were higher and urea was lower than in whole milk. Milk urea revealed the greatest relationships with the other milk parameters, and can be considered as a useful index in studies related to milk production in lactating mares.

Serum concentrations of the major nutritive elements, Mn, Mo, Cu, Fe, Mg, Ca, Na, K, P and Cl, and their interrelationships were evaluated in 20 dairy herds in Urmia, northwest of Iran. Values were determined by atomic absorption, auto analyzer spectrophotometry and flame photometer. Mean Mn, Mo, Ca, P and K were less and Fe and Cu were higher than the reference values. Herd effects were present for the majority of elements, but not K, Na, Fe and Cl. The strongest correlations were positive between Cu/Mo and Ca/Mn, with weaker but significant positive correlations between Mn/Ca, Mo/Cu, Fe/K and Fe/Cl. Negative correlations existed between Ca/K, Ca/Mo, Mg/Mo, Mg/Mn, Mg/P, Fe/Mn, and Fe/Mo. Correlations coefficients with Mo and to a lesser extent Mn were higher than for other elements. There were two principle components in the dataset, explaining 12 and 11% of the variation respectively, involving mainly Fe and Mo in the first component and Ca and Mo in the second. It is concluded that Fe, Mo, Mn and Ca concentrations in the serum of dairy cows in this region were of particular importance in explaining variation in the element concentrations in serum of cows in Urmia, Iran.

From ancient time the human being was familiar with refraction of light through the crystals. One of the earliest finished natural crystals as a lens belongs to 3000 years ago named as Nimrud lens. The purpose of this research was to find when the use of eyeglass was promulgated in Persia

To answer the question, we looked for the first use of the “eyeglass” or its synonyms in the Farsi literature and Persian ancient artistic paintings.

Jami  was the first the Persian poet that used a synonym of eyeglass in his poems. The frequency of its use in Farsi poems has been increased from 16 century onward. We also found two Persian paintings demonstrating the use of eyeglasses in the Safavid period.

Eyeglass was introduced from Europe to Persia. The use of the eyeglasses in Persia was promulgated in the 15th century and early Safavid period onward.

Nowadays, complications of post-operative surgery are major problems for hospitals and occupying hospital beds that lead to the human and financial costs to society and the individual. The aim of this study is to use of appropriate antibiotic as prophylaxis to reduce infection and length of stay in hospital, prevention of drug resistance and postoperative complications.

The present study was carried out on elective surgical patients, including: cholecystitis, inguinal hernia, thyroidectomy and contracture of burn. In this study, the patients were divided into two groups; receiving Cefazolin as prophylactic antibiotic and not receiving Cefazolin.

The results of this study showed that of 618 patients receiving Cefazolin as prophylaxis only 6 patients had postoperative complications and the average length of stay in hospital was 2 days, while in the not receiving Cefazolin group, there were 23 patients of post-operative complications and the average length of stay in hospital was 3.5 days.

According to the findings, antibiotic Cefazolin as prophylaxis reduced post-operative complications and duration of hospitalization.

Gastric cancer is the fourth most common cancer and the second cause of death in the world. According to the study, gastric cancer cells have a relative resistance to chemotherapy. Therefore, the purpose of this study was to evaluate the effect of oral administration of omega fatty acids PUFAs) on lipid peroxidation and oxidative stress in gastric cancer in people with gastric cancer before and after chemotherapy.

This is a double-blind clinical trial. The target group was gastric cancer patients who were first identified and under chemotherapy. Among them, 30 were selected and randomly assigned to two groups. they got. In the control group, the treatment was routine with cisplatin plus placebo. In the case group, treatment with cisplatin plus supplemental capsules of Natural Factors Ultimate-Omega Factors with a dose of 1200 mg per day was 3,600 mg Three tablets of 1200 mg (for three courses) started on horizons three weeks. Three samples of stomach biopsy were taken from all patients before and after chemotherapy. Lipid peroxidation was measured by the Thiobarbituric Acid method and the activity of superoxide dismutase and glutathione peroxidase enzymes by Randox kit. To compare the results, Independent- t-test and Mann-Whitney SPSS software.

In the case group, the percentage of lipid peroxidation of the gastric cancer tissue after omega-unsaturated fatty acids increased significantly (P value less than 0.0001). Omega fatty acids caused a significant reduction in the activity of the enzyme superoxide dismutase in the case group was statistically lower than the control group (P value less than 0.0001)

The results of this study indicate that the use of omega fatty acids as a complement to cisplatin for controlling gastric cancer can be helpful in increasing the amount of oxidative stress and lipid peroxidation of the gastric cancer tissue in this The study was shown.

 Group quarrel is a social pathology phenomenon that disrupts the ruling order of society and dealing with it always has been a concern for social order and security. So, determining the social, economic and cultural effects of Group quarrel tendency among citizens is necessary. The main objective of this research was to examine the impact of factors affecting tend to conflict among male citizens referring to forensic center in Urmia.

The data is obtained through survey-based study and using questionnaire technique of sample of 85 people which were selected through simple random sampling. The information gathered and analyzed using spss version 16 software. In addition to descriptive statistical methods in the statistical analysis, methods such as mean, percentage, variance and analysis of variance and regression were used.

Results showed that 50% of people has a history of conflict and 43% of people do not have any satisfaction of their lives and most of the samples have been selected "the lack of an intimate relationship between family members" from the ones listed in the "Suggested factors affecting the tendency to quarrel". It was found that apart from previous conflict history and dissatisfaction with life, no significant correlation has been found between the results of the investigation and factors affecting the tendency to quarrel among men (P  =0.05).

identify the types of situations and problems affecting the tendency to quarrel among the male citizens referred to forensic center in Urmia, in 2014 will led to further researches on how to prevent and reduce the problems. The data can be used to identify problems that should be considered more in these patients and can be used in health care improvement and awareness of people about the different aspects of this problem and its negative impact on the current state and future of community, the use of health service delivery and training platform to understand and alleviate the problems and eventually the spread of prevention culture and facilities and also family counseling for training families to anticipate and deal with these problems.