a.hajizadeh

Aluminum-containing adjuvants are extensively used for inactive human and animal vaccines owing to their favorable immunostimulative and safe properties. Nonetheless, there is controversy over the effects of different aluminum salts as an adjuvant for the bovine parainfluenza virus type 3 (BPIV3) vaccine. In order to find a suitable adjuvant, we studied the effects of two adjuvants (i.e., aluminum hydroxide [Al(OH)3] and aluminum potassium sulfate [AlPO4]) on the production of neutralizing antibodies (NAbs) for an experimental BPIV3 vaccine. The animals under study (Guinea pigs) were randomly assigned to five groups of experimental vaccines containing Al(OH)3 (AH), AlPO4 (AP), Al(OH)3-AlPO4 mixture (MIX), commercial vaccine (COM), and control (NS). The treatment groups were immunized with two doses of vaccine 21 days apart (on days 0 and 21), and the control group received normal saline under the same conditions. The animals were monitored for 42 days, and blood samples were then taken. The results indicated that all vaccines were able to induce the production of NAbs at levels higher than the minimum protective titer (0.6). An increase in titer was observed throughout the monitoring period. Moreover, an increase in both the level and mean titer of NAbs obtained from the vaccine containing Al(OH)3 adjuvant was significantly higher than in the other studied groups (P≤0.005). The comparison of NAbs titer in other groups did not display a significant difference. Considering the speed of rising and the optimal titer of NAbs production in the experimental vaccine, the Al(OH)3 adjuvant is a suitable candidate for preparing a vaccine against BPIV3 for immunization.

One of the ore dressing steps in Gol Gohar Mining and Industrial Company is dewatering from slurry containing 60 weight percent of the iron concentrate. At present, this dewatering step is carrying out by a continuous strip filter, which is a kind of vacuum filter. At the present research the role of ionic and non-ionic surface activators in reducing the moisture, content of the iron ore particles, after filtration, has been investigated. Surface activators used were sodium dodecyl sulfate (SDS), polyethylene glycol 4000 (PEG4000), sodium dodecyl ether sulfate (SLES) and acetyl tri methyl ammonium bromide (CTAB). In this work amount of 30, 45, 60, 75 and 90 g/ton of the mentioned surfactants were added to the slurry. To evaluate effect of each surfactant, in addition to amount of filter cake humidity, other experiments including filtration kinetics, Zeta potential, contact angle measurement, and FTIR analysis on the samples were carried out. The results showed that SDS and SLES anionic surface activators have a significant effect on the reducing cake moisture. The best results obtained at 75 g /ton of the surfactants and the average moisture reduction in filter cake obtained about 2%. On the other hand, polyethylene glycol 4000 had a negligible effect, 0.5%, on the final cake humidity. The results from addition of acetyl tri methyl ammonium bromide (CTAB) showed that using this chemical reagent does not help to the slurry dehumidification.

The expansion of renewable energy sources (RESs (and advances in power electronics have been led to more attention being paid to DC microgrids (DCMGs). DCMGs enable the exploitation of all renewable energy potentials. Along with the advantages of RESs and DCMGs, the use of RESs is associated with the challenges of absence or lack of inherent inertia. Inertia in the DCMGs plays an important role in reducing voltage changes under destructive events such as load change and power change. Therefore, by applying energy storage systems (ESSs) in DCMGs, and inertia emulation the mentioned challenges can be overcome. The proposed control scheme is implemented based on the concept of the virtual supercapacitor in the inner control loop of the ESS interface dual-half-bridge (DHB) converter with DCMG to emulate the inertia. Due to the high efficiency, electrical insulation, inherent soft switching, and the need for a smaller filter, the DHB converter has been used. Finally, a DCMG is simulated in MATLAB / Simulink. The simulation results show the efficiency and flexibility of the proposed scheme in terms of inertia emulation.

Naringenin is one of the most important and abundant known flavonoids found in grapefruit and other citrus fruits. This experimental study aimed to assess the clinical effects and immune responses of naringenin in the animal model of rheumatoid arthritis (RA) according to various reports on its anti-inflammatory effects and modulation of the immune system. To this end, 40 Wistar rats in the weight range of 160-180g were randomly assigned to four groups (n=10) including healthy, control, naringenin, and methotrexate orally treated groups. To induce RA disease, a compound of 200 μl of Freund's adjuvant and collagen type II was injected subcutaneously into the rear footpads of rats. The severity of RA clinical signs was assessed based on a standard scoring method. The treatment lasted for three weeks (days7-28 after induction). The obtained data pointed out that the levels of C-reactive protein (CRP), myeloperoxidase, nitric oxide, IL-17, and IFN-γ cytokines significantly increased in the RA rats, while the level of their serum antioxidants significantly reduced, compared to the healthy rats. The inflammation of the paws and the level of CRP decreased similarly in both methotrexate and naringenin-treated groups. In the naringenin-treated group, a further decrease was detected in serum myeloperoxidase, nitric oxide, and the total antioxidant capacity occurred, as compared to the methotrexate-treated rats. Nonetheless, IL-17 and IFN-γ cytokines levels were further decreased in the methotrexate-treated group. Accordingly, it can be concluded that naringenin can be effectively used for the reduction of inflammatory effects and control of RA disease.

The effect of shell liners on mill performance has been the subject of various studies, but little known about the effect of dry SAG mills end liners on throughput and grinding efficiency. In particular, in the case of dry Aerofall mill types where it has been claimed that the end liners play a key role in the crushing and grinding actions. This paper experimentally characterizes the role of end liners in dry SAG mills with the objective of obtaining a thorough understanding of the effects of end liners design on the load trajectory and SAG mill performance. It was thought the characterization study will lead to design new end liners which eliminate or reduce the shortcomings of the current liners and improve the comminution efficiency mainly by prolonging liner life. The test works conducted in a scale down mill with a diameter of 1m indicated that conventionally used "deflector" type liners did not provide efficient environment for grinding. Direct observations obtained from the model mill during tests by various visualization techniques, along with simulations using the KMPCDEM software were the main sources of understanding flow behavior of charge inside the mill. In this research, to improve the grinding efficiency, a new design using low profile end liners incorporating radial ribs of proper height was investigated. The special design of model mill made it possible to increase the radial ribs height in steps of 6mm up to 18.5mm. The transparent end of the mill enabled accurate trajectory determination by image analysis. The results indicated that the new lower height profile deflectors and 15.5mm-height (14.5cm in industrial scale) radial ribs improved the mill performance while avoiding excessive pressure drop across the mill and wear on the liner. The image analysis showed that the use of new liners increased the distribution of coarse particles across the mill cross section from 28% to 35%. A new liner design was proposed by decreasing the number of liners in each slice from 5 to 4 pieces. The thickness of the inner head liners reduced from 45cm to 30cm and the outer deflector liners replaced by14.5 cm radial ribs. The distance between the feed and discharge liners increased from the original 115cm to 176cm which increased the effective length of the mill by 53%. The new design reduced the weight and volume of end liners by 9% and 23%, respectively. On account of installation of the new liners in Aerofall SAG mills the throughput increased from 441 to 465 t/h, the product size decreased from 519 to 480 μm and the amount of recycled material from the SAG mill product decreased from 10 to 6%. The most significant improvement was observed in the liner life; an increase of 50 to 200 % in liner life depending on the location of end liners was achieved. The relining time also reduced by 37.5% with the new liners.

The present study aims to evaluate the effects of fracture mechanism on physical parameters such as size, shape, and specific surface area and to provide a description on how the grinding mechanisms of ball mill and High-Pressure Grinding Roll (HPRG) work. Moreover, the effects of these parameters on qualitative indicators of green pellets were also investigated. Furthermore, the amount of fine particle and surface shape of the obtained particles were compared. Results showed that the specific surface area of particles produced through HPGR is more than Ball Mill. This feature was recognized as the result of the increasing fine particles in the range of 7-25 µm and the presence of micro and macro cracks and fractures on the surface of the most particles manufactured by HPGR. In addition, pelletizing processes of HPGR and ball mill products at the same particle size distribution of 80% less than 43 and 90 µm showed that green pellets produced with HPGR product in d80=90 µm have more drop number and compressive strength in both dry (D.C.S) and wet (W.C.S) modes compared to ball mill. Also, the green pellets produced from HPGR product at d80=43 µm had higher drop number and W.C.S than ball mill product. But, compressive strength of green pellets in HPGR product showed 63.18% lower values of D.C.S than pellets produced by ball mill product at d80=43 µm. The reason for the lower D.C.S of the HPGR product is the increase of fine particles and specific surface area that consequently led to high water absorption by the fine particles.

Voltage stability improvement, when overloading of current distribution network is leading it toward voltage collapse, has been deemed as an important criteria in networks including distributed generation units (DGs) as part of it. In this condition, DGs can be leveraged to improve reactive power through voltage control and thus, stabilizing network with respect to the voltage. In this paper, a forward-backward power flow with respect to a voltage stability index (VSI), optimal size and location of DGs within the network are to found. The proposed method are simulated on the 34-bus IEEE standard in order to cross validate the results.

Puberty as a stage of life is an important developmental process. Teen girls have numerous health care needs and their specific issues should be considered. This study was conducted determine the effect of health belief model in adopting prevention and control of health behaviors during puberty among female high school students in Ardakan city.

This study is a randomized clinical trial of an intervention and non-intervention type. The parhicipants were the first grade secondary school students in the city of Ardakan. The sample was randomly selected. Sample size was 120 being estimated on the basis of similar studies. Data were collected by means of questionnaires. To measure the reliability of the questionnaire، content validity and test-retest reliability were applied. Data were analyzed by SPSS software using indicators such as central tendency and dispersion، paired T-test، chi-square، Spearman correlation coefficient، and ANOVA analysis.

After the intervention، the mean score، perceived susceptibility، perceived severity، perceived benefits، perceived barriers، self-efficacy and behavior of non-intervention in the intervention group had a statistically significant difference، but for the mean action، significant differences were not observed. Knowledge score، perceived severity، perceived benefits، perceived barriers، self-efficacy and behavior before and after the intervention in the control group was statistically significant different، however، the mean score for perceived susceptibility، a cue to action، no significant difference was observed. The mean score of knowledge، perceived susceptibility، perceived severity، perceived benefits، perceived barriers، perceived self-efficacy، action and behavior before and after the educational intervention showed statistically significant difference.

The efficacy and efficiency of the health belief model in adopting of preventive behaviors and controls in adolescent girls about puberty health is supported.