javad fadaee
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The urticaria control test (UCT) is a patient-reported outcome measure (PROM) for chronic urticaria (CU) patients. As a Persian version of the UCT was not available, the present research aimed to develop such a version, to test its reliability and validity as well as to evaluate urticaria control among Persian-speaking patients.This research was conducted at the Urticaria Centre of Reference and Excellence (UCARE) of Ghaem Hospital, Mashhad, Iran. In a first step, a linguistically validated Persian version of the UCT was developed through a structured forward and backward translation process and subsequent cognitive debriefing interviews. In a second step, the Persian version of the UCT was completed by 100 well-characterized CU patients together with two anchor instruments, the Chronic Urticaria Quality of life Questionnaire (CU-Q2oL) and the urticaria activity score (UAS), to obtain information on its internal consistency reliability and convergent validity.The Persian version of the UCT was found to have acceptable internal consistency reliability with a Cronbach's alpha coefficient of 0.68. In addition, the results obtained with the Persian UCT correlated with the CU-Q2oL total score (-0.48, p<0.001) and the UAS (-0.404, p˂0.001), suggesting convergent validity. Virtually all patients had poorly controlled CU (UCT<12).A Persian version of the UCT is now available and may help to improve the assessment and monitoring of disease control in Persian-speaking CU patients and to optimize treatment decisions.
Keywords: Chronic urticaria, Patient reported outcome measures, Quality of life, Reproducibility of results -
Substance P (SP) is a neurotransmitter emitted from neurons that plays a role in the pathogenesis of itching conditions including chronic urticarial (CU). The present research aims to investigate the serum level of S.P among CU patients and compare them with healthy subjects and explore how it correlates with the severity of urticaria. The present research was conducted on 87 CU patients who visited the allergy clinic of Ghaem Hospital, Mashhad, Iran from October 2017 to June 2018. Besides, 86 healthy subjects were recruited as the control group. Background information of patient was collected including age, sex, duration of the disease and the co-occurrence of angioedema. S.P serum level was measured in two groups by ELISA method. In the patients group, the autologous serum skin test (ASST) was performed along with the urticaria evaluation questionnaire include Urticaria Activity Score 7 (UAS7), Urticaria Control Test (UCT) and Chronic Urticaria Quality of Life (CU-Q2OL). Among the patients, the SP serum level showed to be about two times higher than the healthy subjects (p˂0.001). SP showed to be increased as patients’ age grew (p=0.010). In patients with a positive ASST, SP level was higher (p=0.012). No correlation was found between SP and the presence of angioedema among patients. There was no correlation between the SP serum level and the scores obtained from urticaria evaluation questionnaires. SP among CU patients was higher than healthy subjects. SP was also higher among female, older and positive ASST patients. The SP value was not correlated with the severity of urticaria, angioedema. In conclusion, Using SP antagonist drugs could be a potential treatment for chronic urticaria.
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Background
Respiratory allergies are among the most common allergies in the world with an increasing number of people affected in recent decades. Determination of allergens prevalence in each area is considered as the first step in prevention of allergic diseases and developing novel and more effective immunotherapies. The aim of this study was to determine the prevalence of the most common allergens among patients with respiratory allergies in Mashhad, Iran
Materials and MethodsThis cross sectional study included 1246 people who were referred to Allergy Clinic of Mashhad University of Medical Sciences with respiratory allergic symptoms from 2012 to 2017 in which a questionnaire containing demographic information was completed and Skin Prick Test was performed for each patient.
ResultsAmong 1246 patients with respiratory symptoms, there were 1084 patients with allergic rhinitis (87%), 69 patients with allergic asthma (5.5%), 14 patients with allergic rhinoconjunctivitis (1.1%) and 79 patients with both allergic rhinitis and asthma (6.3%) with an overall male to female ratio of 1.18. Rhinorrhea (86.3%), sneezing (81.1%) and itchy eyes (68.4%) were the most common symptoms in patients with respiratory allergic disorders in this study and the highest rate of sensitivity was to pollens including Salsola kali (82.3%), pigweed mix (65.1%), tree mix (51.7%) and ash (49.8%), respectively.
ConclusionGenerally, Salsola kali seems to be the main allergen in different respiratory allergies including allergic rhinitis, asthma and rhinoconjunctivitis in semi-arid climate of Mashhad, Iran.
Keywords: Allergens, Respiratory allergies, Rhinitis, Asthma, Rhinoconjunctivitis -
BackgroundUrticaria is one of the most commonly diagnosed pediatric skin disorders. Limited studies have been carried out to investigate acute urticaria-related allergens in Iranian children.ObjectivesThe purpose of this study was to evaluate the prick test findings in Iranian pediatric patients with acute urticaria.MethodsThis cross-sectional study was performed on pediatric patients with acute urticaria September 2012 to 2017. Background data, such as age, gender, and history of other allergic diseases, were recorded. The subjects experienced the skin prick test to assess allergy to 45 aeroallergens, food, contact and insect allergens.ResultsOne-hundred twenty-nine children (male to female ratio: 1.22) with a mean age of 5.93 ± 4.29 years were studied. The most common food allergens were pepper (21.7%), egg white (20.9%), and walnut (17.8%). The most common aeroallergens were Salsola kali (37.5%), Dermatophagoides farinae (33.6%) and trees (32.6%). The mean age of patients with a positive reaction to sesame, pepper, Chenopodiaceae, Salsola kali, grass, Ash, and trees was higher than subjects with negative results, whereas sensitization to milk, beef, and lamb was common in younger children.ConclusionsAccording to the results of this study, the most common food allergens in Iranian pediatric patients with acute urticaria currently appear to be pepper, egg white, walnut and egg yolk.Keywords: Urticaria, Food Allergy, Skin Prick Test, Children
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IntroductionAtopic dermatitis (AD) is an inflammatory, chronic, relapsing, itchy skin disease with an immunologic basis. This disease is associated with itchy skin lesions (pruritus), dry skin (xerosis) and plaques of eczema. The role of aeroallergens, such as house dust mite (HDM) and food allergens has been proven to exacerbate skin eczema lesions. Alongside drugs such as corticosteroids, topical emollients, antihistamines, tacrolimus, and immune suppressants, phototherapy and subcutaneous immunotherapy (SCIT) also done. SCIT is mostly using for sensitization to mite allergens.Case PresentationWe present a 30 y/o Iranian woman with severe atopic dermatitis and sensitization to Candida allergens. We initiated SCIT with candida allergen and the patient had obvious improvements in her signs and symptoms 3 months after starting SCIT.ConclusionAlthough subcutaneous immunotherapy was only approved for mite sensitization in atopic dermatitis, it should be considered in other aeroallergen sensitizations.Keywords: Atopic dermatitis, Candida, Allergens, Subcutaneous Immunotherapy, Skin disease
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زمینه و هدفهموفیلوس آنفلوآنزا یکی از عوامل بیماری زای مهم در سیستم تنفسی بوده که می تواند باعث عوارض متعدد به ویژه در کودکان شود. این مطالعه با هدف تعیین شیوع سروتیپ های هموفیلوس آنفلوآنزا در مخاط حلق کودکان سالم مراجعه کننده به کلینیک امام علی (ع) شهرکرد انجام شده است.روش بررسیدر این مطالعه توصیفی- تحلیلی، 378 نمونه حلقی به صورت تصادفی از کودکان 1 تا 5 سال مراجعه کننده به کلینیک امام علی شهرکرد در سال 1391 گرفته و با دو روش کشت و PCR بررسی گردید. سروتیپ کل نمونه های مثبت با روش PCR بررسی گردید.یافته هادر این مطالعه 42 مورد (1/11 درصد) حامل هموفیلوس آنفلوآنزا بودند (فاصله اطمینان 95 درصد) که در بین آن ها 34 مورد بدون طبقه بندی و 8 مورد کپسول دار بود. در میان انواع کپسول دار 4 مورد سروتیپ f، 2 مورد سروتیپ b و 2 مورد سروتیپ d داشتند. بین شیوع هموفیلوس آنفلوآنزا با وجود برادر یا خواهر زیر 5 سال (044/0=P) و تحصیلات پدر (041/0=P) ارتباط معنی دار آماری دیده شد.نتیجه گیرینتایج این مطالعه نشان داد که سروتیپ غالب نوع بدون طبقه بندی (بدون کپسول) می باشد. علی رغم شیوع بیشتر سروتیپ نوع f، وفور سروتیپ b به عنوان یک از مهمترین عوامل تهاجمی در کودکان حامل باکتری در این مطالعه، لزوم توجه بیشتر مسئولین بهداشتی- درمانی نسبت به این عامل بیماری زا را خاطر نشان می نماید.
کلید واژگان: شیوع، هموفیلوس آنفلوآنزا، کودکان، سروتیپBackground And AimsHaemophilus influenza is one of the most important pathogens in the respiratory system that can cause several complications especially in children. So, this study was aimed to determine the prevalence of Haemophilus influenza serotypes in the pharyngeal mucosa of healthy children.MethodsIn this analytic- descriptive study, 378 pharyngeal samples were randomly selected from 1 to 5 years old children referred to Imam Ali Clinic in 2012. Samples were analyzed by two methods of culture and polymerase chain reaction (PCR). All the positive samples serotypes were evaluated by PCR.ResultsThere was 42 (11.1%) positive numbers of Haemophilus influenza serotypes in the samples in this study (95% Confidence interval). 8 cases were encapsulated and 34 cases nonencapsulated among them. Among the encapsulated ones, 4 cases were serotype f, 2 cases were serotype b and 2 cases were serotype d. There was a significant relationship between the incidence of Haemophilus influenza and having brother or sister under 5 years old (p=0.044) and father’s education (P=0.041).Conclusionthe results of this study indicated that the nonencapsulated serotype has the highest frequency. The frequency of serotype b is one of the most important invasive serotype in carrier's children, although serotype f has more prevalence. Thus, the findings of this study emphasize that responsible managers need to pay more attention to these pathogens.Keywords: Prevalence, Hemaphilus influenza, Children, Serotype
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