mehran hoseinzadeh

Breast cancer is the most common type of cancer and the leading cause of cancer death among women. According to estimates in 2018, the most frequency of cancer in Iranian women was related to breast cancer with 13776 (12.5%) new cases. Metastasis is a complication of this disease that occurs in 1%-5% of patients. The aim of this study was to investigate the effect of hormone receptors and Her-2 status on metastasis status in patients with breast cancer using logistic regression.

In this retrospective study, medical records of 165 breast cancer patients referred to the Ahvaz Shafa Diagnostic and Treatment Center who underwent surgery during 2006-2014 was recorded. Multinomial logistic regression model was applied to identify the related factors to the metastasis status.

In the studied patients, 35.2% (58 patients) experienced metastasis. In multinomial logistic model, Her-2 status (P = 0.026) and lymph node involvement (P <0.001) were significant. The odds of metastasis in ER-positive individuals was 2.24 times that of ER-negative individuals (AOR=2.24; CI95%: (0.955-5.275)). Also, the odds of metastasis in patients with lymph node involvement was 5.40 times that of patients without involvement (AOR=5.407; CI95%: (2.180-13.414)). This odds in people with Her-2-positive status was 2.35 times than in those with Her-2-negative status (AOR=0.438; CI95%: (1.109-4.999)).

In this study, Her-2-positive status and lymph node involvement were identified as factors associated with metastasis. Early detection of these factors can lead to greater survival of breast cancer patients.

Spinal-Z is a methanolic mixture of dried seed powder of Peganum harmala Linn. and leaf of Dracocephalum kotschyi Boiss. It is available as oral capsules and has been used to treat various cancers. The aim of this study was to evaluate the effects of Spinal-Z capsules (containing herbal extracts) on blood parameters and gastrointestinal symptoms of patients with metastatic gastric adenocarcinoma and to determine its potential side effects.
A total of 76 patients were randomly assigned into 2 groups. The intervention group received 6 Spinal-Z capsules per day (2 after breakfast, 2 after lunch, and 2 after dinner). The control group received placebo capsules in the same manner. The patients were followed-up for 24 weeks.
The distribution of demographic and clinical characteristics was homogeneous in the intervention and control groups. Spinal-Z treatment had no significant effects on cardiovascular parameters, such as systolic blood pressure, diastolic blood pressure, or heart rate, compared to the control group. No significant changes were observed over time, although a significant reduction in fasting blood sugar was observed in the intervention group, compared to the controls. Based on the findings, treatment could significantly reduce dysphagia and stomachache in the follow-up, while it had no significant effects on symptoms, such as itching, nausea, or vomiting neither temporarily nor in the long run (follow-up; P > 0.05).
Spinal-Z does not have any adverse effects on cardiovascular, renal, and hematopoietic systems or blood glucose level. On the other hand, it could improve gastrointestinal complications. Overall, Spinal-Z, as an accessible and affordable medication with very few side effects, may be a suitable option for treating complications in patients with metastatic gastroesophageal adenocarcinoma, as it can decrease fasting blood sugar and erythrocyte sedimentation rate.

The optimal protocol for administration of 5-fluorouracil (5-FU) in chemotherapy of colorectal cancer is unknown..
We compared treatment outcomes of short-time infusion of 5-FU (8-hour infusion) with 22-hour infusion, in chemotherapy management of colorectal cancer..
Patients and A retrospective study was conducted on colon cancer patients, who have been treated for at least 24 weeks with the FOLFOX regimen (5-FU, leucovorin, and oxaliplatin). Patients who had received infusion of 5-FU, either over 8 hours (5-FU 8h) or over 22 hours (5-FU 22h) were selected. The study endpoints were 3 and 5 years disease free survival and overall survival..
A total of 58 patients, in the 5-FU 8h, and 50 patients, in the 5-FU 22h groups, were studied. Based on the intention-to-treat analysis, there was a lower overall mortality (44% vs. 22.4%, P = 0.023) and lower overall relapse (46% vs. 18.9%, P = 0.004), as well as a higher 3 years disease free survival (81% vs. 58%, P = 0.011) in the 5-FU 8h, compared with 5-FU 22h group. The Log Rank test showed a difference between the two groups, for disease free survival (P = 0.008), as well as overall survival (P = 0.014), confirmed by Cox Regression analysis: hazard ratio [95% CI] = 0.365 [0.160 to 0.833] and 0.286 [0.100 to 0.817], respectively..
We found better outcomes for the colon cancer patients, who had received infusion of 5-FU 8h, compared with 5-FU 22h, in the FOLFOX chemotherapy. These findings should be tested in prospective clinical trials..

Recent studies have demonstrated the obese–induced oxidative stress and inflammation are risk factors for breast cancer. The aim of this study was to determine the relationship of the pro-inflammatory markers، lipid peroxidation and body fat percentage after 6 weeks of regular water-based exercise and ginger supplement in obese women with breast cancer.

In a semi-experimental study، forty obese women diagnosed with breast cancer with weight 76±9 kg and fat mass of 41. 8±4 percent were randomly divided into four groups: placebo، water-based exercise، ginger supplement and a combined group of water-based exercise and ginger supplement. Subjects of the ginger supplement and combined group were receiving 4 capsules of ginger powder on a daily basis (each capsule contained 750 mg)، for 6 weeks. The water-based exercise training program was collected at a progressive intensity and time: 4 times a week for 6 weeks.

Implementation of water-based exercise، ginger supplement and the combined programs caused a significant decrease in concentration of interleukin -6 (IL-6) and C-reactive protein (CRP)، malondialdehyde (MDA) and fat mass. However، considering Pearson correlation coefficient، it was concluded that just the relationship between fat mass and MDA in the ginger supplement group was significant (r= 0. 63، p= 0. 05).

Although performing water-based exercise and ginger supplement programs attenuate systemic inflammation and oxidative stress in obese women with breast cancer، there was no relationship between stress and changes of pro-inflammatory markers.