فهرست مطالب mohammad ali shahtalebi

In this study, the effect of adding purified powder of Salvia officinalis on the mechanical properties and bonding ability of resin‑modified glass ionomer (RMGI) cement is investigated.

In this in vitro study Purified powder of S. officinalis with particles smaller than 50 µ, in weight percentages of 0.5%, 0.75%, 1%, and 1.25%, was added to RMGI powder (GC Fuji II LC, GC USA). Fifty samples in five groups of control and percentages that considered, from the powder of GI combined with liquid, according to the manufacturer instructions and prepared samples with 4 mm × 6 mm dimensions and placing in distilled water in an incubator with temperature 37°C for 24 h. Fifty sound extracted upper premolars were collected and divided into five groups. The dentinal cross‑sections on the occlusal surfaces of teeth were prepared and assessed under a stereomicroscope with ×16. Then, samples with 2 × 4 dimensions from RMGI was prepared on dentin surface and keeping in moisture environment in an incubator with temperature 37°C for 24 h. Compressive strength and shear bond strength test done with a universal testing machine at the rate of 0.5 mm/min. For the assessment of mode of failure, stereomicroscope with a digital camera and ×20 was used, and photographs from bonding surface were taken. After collecting data, the ANOVA test was used for comparing shear bond strength between groups and Kruskal–Wallis test was used for comparing compressive strength. The Chi‑square test was used for comparing the mode of failure between groups. The significance level for all tests was considered 5%.

According to the statistical analysis, compressive strength (P = 0.486) and shear bond strength (P = 0.076) were not significantly different between the five groups. The distribution of mode of failure was not significantly different between groups (P = 0.663).

The addition of purified powder of S. officinalis to RMGI powder does not affect compressive strength and shear bond strength of RMGI cement.

Burn is the fourth most prevalent trauma around the world that many people are affected by it every year. One of the common methods of healing burn wounds is the use of Silver sulfadiazine cream 1%, the most important complication of which is the delay in healing of the wound.

This study was done in order to identify and evaluate effective drugs in the treatment of burn wounds, in which the effect of chamomile cream and Silver sulfadiazine cream 1% on second-degree burn wound healing was compared.

This triple-blind clinical trial was performed in Isfahan Burning Incidence Clinic. In this study, 67 patients with the inclusion criteria, with had second-degree burn wounds with an extended range of 1-10%, were randomly assigned to two groups, among whom, 34 patients with chamomile cream and 33 patients with Silver sulfadiazine cream were treated daily up to the time of healing the burn wounds. The duration of healing was evaluated according to a checklist. Data analysis was performed using SPSS software and the statistical tests of Chi-square, Mann-Whitney, independent t-test, and Fisher tests.

Data analysis showed that the mean healing time for wound healing in the treatment group with chamomile cream was 6.26 ± 0.96 day, and 10.42 ± 1.48 day in the Silver sulfadiazine group. Which, There was a significant difference between two groups (P < 0.001).

Regarding the complication of Silver sulfadiazine cream 1% such as delayed wound healing and wound color change, Chamomile cream can be suggested as a natural alternative therapy in the treatment of superficial second-degree burns.

In this study, the anti‑Streptococcus mutans and anti‑Lactobacillus casei properties of a restorative glass‑ionomer cement (GIC) modifed with extract powder of Salvia offcinalis as a safe and effective herbal extract at weight concentration levels of 0.5%, 0.75%, 1%, and 1.25% are investigated. The S. offcinalis extract powder is provided by doing a multistep laboratory procedure and is fltered to obtain particles smaller than 50 µ. The GIC powder is modifed by adding extract powder in weight concentrations of 0.5% (Group II), 0.75% (Group III), 1% (Group IV), and 1.25% (Group V) to form experimental groups, each of 1 g. Five disk‑shaped samples, 1 cm in diameter and 2 mm height, of each group (including control group [Group I]) are prepared for each bacterial category of S. mutans and L. casei. The twenty‑fve samples for each category are tested in vitro against strains of S. mutans and L. casei. Following Agar diffusion tests, the inhibition zone diameters are recorded. The data are tested for normality by means of Kolmogorov–Smirnov procedure. The Kruskal–Wallis and Mann–Whitney tests are used to perform a one‑way ANOVA and to do pair‑wise comparisons, respectively, at 5% signifcance level. The mean diameter of the inhibition zones are signifcantly different among the test groups and also the test groups and the control group except for the group with 0.5% in L. casei category which shows no signifcant difference with the control group. The present study revealed direct inhibitory activitiesof S. offcinalis‑containing GIC against S. mutans and L. casei in a dose‑response manner.

Pramipexole is the mostly prescribed drug in patients with Parkinson disease. The incidence of Parkinson disease is related to aging and mostly developed in elderly people with difficulty in swallowing or dysphagia. In the current study we aimed to develop an orally fast disintegrating tablet (ODT) of pramipexole as a preferable alternative in geriatric patients. Hence, the fast disintegration is a critical criteria for ODTs, the effects of four different superdisintegrants including, crospovidone, croscarmellose, sodium starchstearate glycolate, and agar were evaluated on physical characteristics of the tablets. All of the formulations were prepared through direct compression method using aspartame and manitol as taste masking agents. The flow properties of all of the mixtures were in the acceptable limits. Croscarmellose and Avicel® were chosen as the best superdisintegrants which resulted in the lowest disintegration disintegrating time and the least friability. In subsequent studies, a 32 full factorial design was adopted to assess the impact of different amounts of croscarmellose and Avicel®. The overall results suggests that the tablets containing 2.5 mg croscarmellose and 70 mg Avicel® as superdisintegrants isare the best formulation. Mean hardness, disintegration time, friability, and the drug release percent during 5 min for the optimized formulation were confirmed 42.05 ± 4.6 Kg/cm2, 24.98 ± 6.8 Sec, 0.13 %, and 95.52 ± 2.23% , respectively.

Antirrhinum majus contains aurone with excellent antibacterial and antifungal activities. In addition, visible light activates the endogenous porphyrins of Propionibacterium acne, which results in bacterial death. Therefore, considering the above‑mentioned facts, the aim of the present study was to prepare a topical herbal gel of A. majus hydroalcoholic extract and to evaluate its antiacne effects with or without blue light combination as an activator of the porphyrins.

Antibacterial activity of the shoot or petal extracts was evaluated by disc diffusion method and the minimum inhibitory concentration (MIC) was calculated. Various gel formulations were developed by the Experimental Design software. The obtained gel formulations were prepared and tested for pharmaceutical parameters including organoleptic features, pH, viscosity, drug content, and release studies. Finally, the antibacterial activity was evaluated against (P. acnes) with or without blue light.

The MIC of the extracts showed to be 0.25 μg/ml. Evaluation of the gel formulation showed acceptable properties of the best formulation in comparison to a gel in the market. Pharmaceutical parameters were also in accordance with the standard parameters of the marketed gel. Furthermore, statistical analyses showed significant antibacterial effect for gel when compared to negative control. However, combination of blue light with gel did not show any significant difference on the observed antibacterial effect.

Because of the statistically significant in vitro antiacne effects of the formulated gel, further clinical studies for evaluation of the healing effects of the prepared gel formulation on acne lesions must be performed.

Painful menstruation or primary dysmenorrhea is a common condition among women and is one of the causes of referring to obstetrics clinics. Although primary dysmenorrhea is not life threatening, but it has adverse effect on quality of life in young women and causes insufficiency in severe cases. Therefore, this study was performed with aim to evaluate the effect of zinc acetate capsule on the intensity of primary dysmenorrhea.
This double-blind randomized clinical trial was performed on 78 students (18–25 years old) residing in dormitory of Falavarjan Azad Islamic University in 2014. The subjects were randomly assigned into zinc acetate or placebo group and completed the daily status recording form during 3 first day of mensturation. The experimental group received 30 mg of Zinc acetate capsule daily for two consecutive cycles. Data was collected by the questionnaire and as self-report. Data were analyzed by Wilcoxon and Mann Whitney tests by SPSS software (version 21). P Before the intervention, there was no significant difference between two groups in terms of demographic variables and mean of pain intensity (P>0.05), but, pain intensity decreased in both groups after the intervention compared to before the intervention (P Zinc acetate which is a non-pharmacologic complementary can decrease the pain intensity and can be used for treatment of primary dysmenorrhea.

From a consumer perspective, developing a hair care formulation that offers multi-purpose products to enhance routine hair care such as conditioning, cleaning and grooming hair and stimulating hair follicles is important. Eugenol comprising about 70% of clove essential oil shows an androgenic activity and stimulates hair root to feed and hence could be a good candidate for developing an anti-hair loss formulation. Thus in hair research, hair follicle is of great interest. The aim of this study was to develop a self-emulsifying product containing eugenol in emu oil as a carrier.
Eugenol was identified in clove oil extraction by UV spectrophotometer. Emu oil was characterized according to national oil standards. All formulations were prepared and best one was selected for further pharmaceutical examinations such as pH, particle size, content uniformity and drug release. The optimum formulation was clinically evaluated on rats back compared with minoxidil standard lotion as a positive control and distilled water as a negative control.
The selected formulation was demonstrated to condition hair with grooming and enhanced hair growth with longer lag time compared with minoxidil but after one week the hair growth accelerated.
The formulation containing clove oil in emu oil self-emulsion shows a conditioning and grooming property with hair shaft repair and hair growth.

Skin aging starts at around age of 30 with wrinkling and pigmentations as its mainindicators. Delay and prevention of aging is a major concern for a great number of people. Thepurpose of this research was to develop and evaluate the efficacy of an anti-wrinkle tomato lotion,consisting of 5% w/w tomato powder in an oil-in-water (O/W) emulsion. Different O/W emulsions were prepared and stability tests were done on them. Theformulation that successfully passed the stability tests, was chosen and the Solanum lycopersicumpowder was added to the oily phase of this O/W emulsion. The prepared lotion was evaluated forpharmaceutical tests. In vitro permeation studies were performed to measure permeation throughcellulose acetate membrane by diffusion cell at sink condition. In vivo trial for examination of theanti-wrinkle efficacy of lotion was done on 10 healthy women as case group compared with 10volunteers using the placebo lotion (lotion base without Solanum lycopersicum powder) as controlgroup. According to the experimented results on the formulated lotion, the efficient time durationfor lotion effectiveness was 42 days. Tomato powder formulated in base of lotion significantlydecreased wrinkles. Our formulation was compatible with skin and caused no sensitivity reactionin human models The Lycopene in Solanum lycopersicum in this formulation has anti-aging effect. Thisformulation might be a strong candidate for treatment of skin wrinkles.

Rizatriptan benzoate is a potent and selective 5-HT1B/1D receptor agonist and is effective for the treatment of acute migraine. Difficulty in swallowing is common among all age groups, especially elderly and pediatrics. Orally disintegrating tablets may constitute an innovative dosage form that overcome the problem of swallowing and provides a quick onset of action. This study was aimed to formulate and evaluate an Orally Disintegrating Tablet (ODT) containing Rizatriptan while using semi-synthetic and natural superdisintegrants. Orodispersible tablets were prepared by direct compression using natural superdisntegrant (Plantago ovata mucilage) and semi-synthetic superdisntegrant (crospovidone). The prepared tablets were evaluated for hardness, friability, thickness, drug content uniformity, water absorption and wetting time. A 32 factorial design was used to investigate the effect of independent variables (amount of crospovidone and Plantago ovata mucilage) on dependent variables [disintegration time, wetting time and Q5 (cumulative amount of drug release after 5 minutes)]. A counter plot was also presented to graphically represent the effect of independent variable on the disintegration time, wetting time and Q5. The check point batch was also prepared to prove the validity of the evolved mathematical model. The systematic formulation approach helped in understanding the effect of formulation processing variable. According to the results of optimized batches, the best concentration of superdisintegrant were as follows: 9.4 mg Psyllium mucilage and 8.32 mg crospovidone gave rapid disintegration in 35sec and showed 99% drug release within 5 minutes. Plantago ovata mucilage, a natural superdisintegrant, gives a rapid disintegration and high release when used with synthetic superdisntegrant in formulation of orally disintegrating tablet of Rizatriptan.

Difficulty in swallowing (dysphagia) is common among all age groups, especially in elderly and children. Orally Disintegrating tablets constitute an innovative dosage form that overcomes the problems of swallowing and provides a quicksetof action. The purpose of this study was to formulate and evaluate an orally Disintegrating Tablet (ODT) containing captopril while using croscarmellose sodium, crospovidone and two natural superdisintegrants: karaya gum and natural agar. For the preliminary study 12 batches were prepared. A 32 full factorial design was applied to optimize the formulation and 9 batches were prepared and evaluated. From the preliminary study it was found that ODTs containing karaya gum showed a better disintegration time and hence it was considered for further studies.

Deodorant products prevent the growth and activity of the degrading apocrine gland bacteria living in the armpit. Common antibacterial agents in the market like triclosan and aluminum salts, in spite of their suitable antibacterial eff ects, increase the risk of Alzheimer’s disease, breast and prostate cancers or induce contact dermatitis. Th erefore, plant extracts possessing antibacterial eff ects are of interest. Th e aim of the present study was to verify the in vitro antimicrobial eff ects of diff erent sage extracts against two major bacteria responsible for axillary odor, and to evaluate the deodorant eff ect of a silicon-based stick containing sage extracts in diff erent densities in humans. Diff erent fractions of methanolic extract of Salvia offi cinalis (sage) were evaluated on a culture of armpit skin surface of volunteers through agar microdilution antimicrobial assay. Th en, randomized, doubleblind placebo-controlled clinical trial with the best antibacterial fraction was conducted on 45 female healthy volunteers. Participants were treated with a single dose in four groups, each containing 15 individuals: Group 1 200 g/mL), 2 (400 g/mL), 3 (600 g/ mL) of dichloromethane sage extract, and placebo (without extract). A standard sensory evaluation method for the evaluation of deodorant effi cacy was used before, and two hours, four hours, and eight hours after single application of a deodorant or placebo (ASTM method E 1207-87 Standard Practice for the Sensory Evaluation of AxillaryDeodorancy). Th e data were analyzed with two factors relating to densities and time. In 45 participants with a mean [± standard deviation (SD)] age of 61.5±11.8 years, statistically signifi cant within-group diff erences were observed before and two, four, and eight hours after deodorant treatment for groups 1, 2, and 3. Groups 1, 2, and 3 had a signifi cantly smaller odor score than placebo after two, four, and eight hours (P < 0.001). In a comparison of diff erent deodorant densities, the interaction eff ect was not signifi cant between deodorant 200 and 400 g/mL, but was signifi cant between 200 and 600 and between 400 and 600 g/mL sage extract sticks (P < 0.001). Before running the sensory evaluation of the deodorant sticks on the subjects, a rabbit skin patch test was used to demonstrate that the formulation had no irritants. A single treatment with a stick deodorant containing dichloromethane sage extract of 200, 400, or 600 g/mL concentrations was eff ective in reducing the axillary malodor level compared with the control, in healthy subjects.

Foot ulcers and infections are the major sources of morbidity in individuals with diabetes mellitus.This study aimed to evaluate the efficacy of topical Royal Jelly (a worker honey bee product) on healing diabetic foot ulcers. Diabetic patients with foot ulcers that were referred to our clinic at Khorshid Hospital, Isfahan, Iran; were evaluated three times a week and treated according to standard treatments consisted of offloading, infection control, vascular improvement and debridement if required. In addition, all ulcers were measured and then topical sterile 5% Royal Jelly was applied on the total surface area of the wounds. Eventually, they were covered with sterile dressings. Each patient was followed for a period of three months or until the complete healing. A total of eight patients were enrolled in this study. Of these, two had two ulcers and, therefore, ten ulcers were evaluated. Two ulcers were excluded. Seven of the remained eight ulcers healed. Mean duration of complete healing was 41 days. One ulcer did not completely heal but improved to 40% smaller in length, 32% in width and 28% in depth. The mean length, width and depth reduction rates were 0.35 mm/day, 0.28 mm/day and 0.11 mm/day, respectively. Royal Jelly dressing may be an effective method for treating diabetic foot ulcers besides standard treatments.