mohammad banazadeh

Sexuality remains a subject of ongoing debate, with significant implications for self-perception and self-esteem, and addiction is a factor that can adversely affect it. Sexual dysfunction heavily burdens people with substance use disorders, as it can cause severe issues such as erectile dysfunction, loss of libido, dyspareunia, and delayed ejaculation. These issues can be caused by hormonal imbalances, loss of vaginal lubrication, lowered blood flow to the penile tissue, and problems with other organs, such as the liver. There could be some therapies to resolve such issues at least partially, for example, medication (oral and injectable), low-intensity focused shockwave therapy, vacuum constriction device, promoting exercise, and testosterone replacement therapy. Utilizing such methods could be helpful, but we could not be sure of their effectiveness. The current review aims to give a brief overview of sexual function, substance use disorders, and their impact on sexuality.

Context: 

Despite major advancements in the field, the current neurosurgical practice requires an interdisciplinary approach. It is known that surgical practice and other cancer-eliminating treatments can be combined for optimal results. However, recent attempts have failed to address many debilitating conditions, indicating an emergent need for novel interdisciplinary therapeutic approaches.

Evidence Acquisition: 

We searched PubMed and Google Scholar for the keywords “immunoinformatics,” “in silico,” “neurology,” and “neurosurgery.” Without time restriction.

 The immune system is versatile because it is involved in physiological brain function and affects the course of central nervous system (CNS) disease and infection. A novel approach combines neurosurgery and immunoinformatics for optimal results. For instance, brain tumors, such as glioblastoma multiforme (GBM), are still associated with a severely reduced survival of patients, and resection of tumors may provide little help. In silico approaches could help to identify molecular pathways and design immunotherapies for such conditions at a significantly increased speed compared to traditional vaccinology approaches.

 The neurosurgical practice could be affected by different infectious organisms. These organisms can be targeted by in silico vaccinology techniques. Here, we provide a brief overview of bioinformatics/immunoinformatics and discuss the possible role of immunoinformatics in neurosurgery. In light of the current Coronavirus disease-2019 (COVID-19) epidemic, projections for future studies are also included.

Psychological stress is associated with unhealthy lifestyles, including smoking. Moreover, religiousbeliefs can play a significant role in relieving mental disorders such as anxiety and stress. Due to the frequentexposure of medical students to stressful situations, this study was conducted with the aim to investigate therelationship of internal and external religious orientation with perceived stress and nicotine dependence. This correlational study was carried out on medical students of Kerman University of MedicalSciences, Kerman, Iran, in 2015. The sample size was determined to be 224 individuals using the Morgantable. The participants were selected using stratified random sampling. The data collection tools consisted ofa demographic information form, the Religious Orientation Scale (ROS) (Allport and Ross), the PerceivedStress Scale (PSS-14), and the Fagerstrom Test for Nicotine Dependence (FTND). Data were analyzed usingmultiple regression analysis, analysis of variance (ANOVA), Pearson correlation coefficient, and t-test inSPSS software. The findings of the study showed that internal religious orientation had a significant negativerelationship with perceived stress and nicotine dependence; however, no significant relationship wasobserved between external religious orientation and these variables. Based on the results of the study, it can be concluded that the religious beliefs of individuals havea preventive role in perceived stress and nicotine dependence.

Although esophageal liposarcoma is an extremely rare tumor, liposarcoma is the most common soft tissue sarcoma in adults. Liposarcoma is currently classified into the types of well-differentiated, myxoid, round cell, pleomorphic and dedifferentiated liposarcoma. Up to now only a few cases of esophagus liposarcoma have been described in the world literature. We describe a myxoid type liposarcoma of the esophagus in a 68 year old man presented with hoarseness and intermittent dysphagea to solid food. He had a huge mass in his mouth which was mobile with gag reflex. A barium swallow, esophageal manometery and CT scan of the esophagus have not clearly revealed the mass. After endoscopic surgical resection of the tumor the histological examination revealed a myxoid liposarcoma. Both the presenting signs and symptoms and the histology type are rare for such tumor. This case demonstrate a rare differential diagnosis of intermittent dysphagia as early diagnosis is so important in those tumors and should kept in mind them, although they are quite rare.

Visual, brain stem auditory and somatosensory evoked potentials (EPs) have been traditional paraclinical tests to evaluate the competency of sensory tracts in MS patients. It seems that only one of these EPs could be sufficient, at least as a screening test. The objective of this paper is to evaluate the frequency of these three evoked potentials in definite MS patients. This descriptive cross-sectional study involved was 25 definite relapsing remitting MS patients who referred to our university hospital. Twenty five individuals from normal population without any neurologic, visual, auditory or sensory disorders have been evaluated as well to determine the standard values in our electrophysiology lab