mohammad moosavi

Inositol-requiring enzyme 1 (IRE1), an endoplasmic reticulum (ER) transmembrane protein with both kinase and endoribonuclease activities, plays an essential role during ER stress and its subsequent unfolded protein response (UPR). Recent evidence shows IRE1 signaling contributes to tumorigenesis and cancer progression, pointing to the therapeutic importance of this conserved arm of the UPR. Here, we employed different computational tools to design and predict short peptides with the capability of disrupting IRE1 dimerization/oligomerization, as a strategy for inhibiting its Kinase and RNase activities. A mutation-based peptide library was constructed using mCSM-PPI2 and OSPREY 3.0. The molecular interaction analyses between the designed peptides and IRE1 protein were conducted using the HADDOCK 2.2 online server, followed with molecular dynamics analysis by the GROMACS 2020 package. We then selected short peptide candidates that exhibited high affinity and best predicted physicochemical properties in complex with IRE1. Finally, online servers, such as ToxinPred and AllerTop, were used to identify the best peptide candidates that showed no significant allergenic or cytotoxic properties. These rational designed peptides with the capability of binding to IRE1 oligomerization domain can be considered as potential drug candidates for disrupting IRE1 activity in cancer and related diseases, pending for further validation by in silico and experimental studies.

Mulla Sadra’s rational explanation of “termination of the after death torment” came under Sabziwari's several criticisms. He has leveled two criticisms to Mulla Sadra’s point of view: first is based on the denial of the “no compulsion persists” rule, and second on that the God-given innate nature does not go away, even as to those who shall suffer due to their nature and temper. Sabziwari holds that through regular practice evil habits go implanted in the soul of damned people as an inseparable part of their nature. Therefore, there will be no room to resort to the "no compulsion persists" rule in order to prove the termination of torment. Furthermore, it is incorrect to argue that the torment of some people depends on their temper and required nature, because the God-given nature keeps exiting. According to Mulla Sadra’s viewpoint, however, none of the two criticisms are acceptable, because he merely applies the rule to one case and one particular people of hell punishment; the very viewpoint is embraced by Sabziwari himself, too. Accordingly, Mulla Sadra has never held that the God-given nature of all people in hellfire goes away. In this essay, the authors have comparatively and analytically examined this issue in detail.

Rheumatoid arthritis (RA) is an autoimmune disease caused by accumulation of numerous inflammatory cells in the joints and secretion of various cytokines leading to cartilage and bone damage. IL-17 and IL-23 are inflammatory cytokines that their definite role has not been clearly distinguished in RA pathogenesis. Therefore, this study aimed to investigate the expression and association of IL-17 and IL-23R in Peripheral Blood Mononuclear cells (PBMCs) in RA patients.
This study was case-control. We gathered peripheral blood from 37 patients with RA and the same number of healthy individuals as a control group. In brief, PBMCs were isolated by Ficoll centrifugation. After RNA extraction and cDNA synthesis, IL-17 and IL-23R expression mRNA levels were determined in PBMCs by real-time PCR technique and Taqman probe method.
The mean±standard deviation of the ages in patient group was 46.86±1.328 yr. and in controls was 44.73±1.392 yr. The expression of IL-17 was increased in RA patients in comparison to healthy controls (P= 0.002). Whereas, after comparison of IL-23R expression in patient and healthy groups, no significant difference was observed (P = 0.22).
In this study, upregulated expression of IL-17 implicated the important role of this cytokine in RA pathogenesis. Therefore, novel therapeutic and more effective strategies can be suggested by further investigations to specifically inhibit IL-17 using monoclonal antibodies (biologic drugs)

Temperature is one of the most basic meteorological parameters of frequency applications in agricultural science and technology. The aim of this study was to compare the data recorded in a standard synoptic weather station (Rasht agro meteorology station) and temperature recorded in rice fields and in the average canopy height of rice.
Material and For this purpose, the temperature of paddy field installed in standard screen box is measured in 65 cm in height using thermograph and thermometer, and it was compared with the data of the Agricultural Meteorological Station in the vicinity of the farm.
Results show that temperature changes during the season at the station and farm and in all measurements are incremental, but the increase in the maximum is higher than the minimum. The mean comparisons of the canopy have a significant difference in measurements of farm and the station. Differences in maximum temperature are greater than the minimum temperatures, indicating that the effect of farm microclimate on reducing the maximum temperature is more effective. The differences of field (daily) thermometer and stations in the whole season were between 1.1 and 6.1 degrees Celsius respectively in average temperature and maximum, but no significant difference in minimum is seen. In this study, growing degree days (GDD) calculated from three sources has significant differences and reflects the importance of accuracy in the calculation of these parameters in agricultural meteorology. Before the end of the growth phase (Phase II) there is no significant difference between the thermometer in field and station, so station data can be used directly instead of field data. Most differences are seen in the middle stage and end-stage growth (0.9 and 2.3 degrees Celsius on average and 1.4 and 2.9 degrees Celsius of the maximum). Maximum and mean temperatures of the whole period at stations with coefficients of determination values, 0.79 and 0.74, can be converted to farm temperature. By stopping irrigation and entering to complete maturity, the similarity between the field and the station records become greater. Because minimum temperatures last longer than the maximum and there is sufficient time for thermometer to be adjusted to the environment, the registered minimum in the thermograph has less difference than the maximum data in comparison of the same elements in stations.
Development of canopy causes significant differences between data recorded in paddy field and station and difference in maximum temperature is more than minimum temperature. The accuracy of data which is measured by thermograph and to extract maximum and minimum temperatures, it is important to consider the persistence of the temperature, If the temperature continues longer hours it has probably more accurate results. However both maximum and minimum temperatures have increasing trend, the difference between maximum and minimum increase during the season in all methods. Rain reduces the difference between the maximum and minimum temperature. With the interruption of irrigation and reaching maturity stage, the difference between the station and the farm is not meaningful.

in present research, balanced scored card has been developed to assess affiliate organizations to municipality. In spite of various designed models to assess performance of the sub-departments of Mashhad municipality, there is not a model that can consider the organization's natural differences sides together with their performance sides. Hence, the aim of this research is designing a model that considers the factors which are out of control of affiliate organizations that are effective on their performance besides presenting performance indices. In another words, the research is intended to answer the question that which internal and external factors affect on performance of affiliate organizations to Mashhad municipality indeed and what is the part of each one? The research is an applied research in terms of purpose and is a qualitative one in terms of gatherind data. In order to take the expert's ideas that included managers of all organizations and affiliate organizations to Mashhad municipality (14 organizations and 6 affiliate agency), Delphi method was utilized. The ultimate designed model included 7 indices of financial clustering, 2 indices of customer clustering, 5 indices of process clustering, 2 indices of growth clustering, 7 indices of financial performance, 4 indices of customer performance, 7 indices of process performance and 7 indices of growth performance. This research helps top managers of Mashhad municipality that how they can monitor the performance of affiliate organizations regarding natural characteristics of each of them.

The aim of this study is to investigate human resource competencies in Iranian Petroleum Company. This study is a descriptive-analytical approach. In this research, we examined human resource competencies in six main categories including; credible activist, culture & change steward, talent manager/organizational designer, strategy architect, operational executor, business ally, as well as 21 sub indicators. To collect data, we used a designed questionnaire with 60 items. The collected data were analyzed by T-Test and Confirmatory Factor Analysis tests. The results showed, all of human resource competencies recorded above average score. Also the results showed that strategy architect and business ally had the highest average and the culture & change steward had the lowest average. The research also revealed that strategy architect and credible activist have the lowest and highest correlation with Human resource competencies respectively. According to the results, it is suggested that managers need to identify skills relevant to these competencies, and take necessary steps to learn and practice them.

Alzheimer disease is a neurodegenerative disorder, that characterized by memory loss and cognitive functions. The aim purpose of this study was to evaluate the serum magnesium level in Alzheimer patient and its relationship with diseases severity. In a case-control study, 69 patients with AD (Alzheimer's disease) were studied in 15 month period. Seventy one age and sex-matched healthy person also included as controls. Disease severity of was determined by global decay score (GDS). A serum magnesium level was measured by Atomic Absorption Method. In the patient and control groups. The evaluated relationship between serum magnesium levels with disease severity. Sixty nine patients (M/F=37/34, mean age 71.12±5.81 years) and 71 healthy persons (38/31, M/F) mean age (69.73±5.18 year) were enrolled in this study. Serum magnesium level in case and control groups was 1.7±0.2 ppm and 1.8±0.3 respectively and it was significantly lower in AD patients (P=0.001). There was no meaningful relationship between magnesium level and disease severity (P=0.75). This study showed a statistically meaningful difference between serum magnesium level in patient with AD and healthy individuals but there was no relation between the level and disease severity.