r. vafaee

One of the shortcuts to disco-ver drug targets is the utilizing of new kn-owledge of basic medical sciences such as genomics، proteomics، metabolomics، bio-informatics and biostatistics that are apply-ing holistic approaches to study biological and medical subjects. In this study pro-teomics، bioinformatics and biostatistics techniques were applied to identify prob-able therapeutic proteins targets for the treatment of Alzheimer''s disease. Hippoc-ampus proteomes of normal and Alzhe-imeric rats treated with aqueous extract of lavender were evaluated with protein expr-ession clustering method.

Proteins of hippoc-ampus samples from normal and Alzheim-eric rats that treated with aqueous extract of lavender (CE and AE) and without the extract (C and A) were extracted. Proteins were separated by using of two-dimensional gel electrophoresis and the gels were stai-ned by silver staining methods. Bioinfo-rmatics and biostatistics analysis of the separated were accomplished by bioinfo-rmatics software.

Bioinformatics and statistical analysis of the stained gels obtained 990 proteins in the four groups of rats. Prote-omic comparison of A and AE groups reve-aled that the expression of 49 proteins was inhibited، while the expression of 26 new proteins in the AE group was observed that may be due to the present of lavender extract. Proteomic comparison between gro-ups C and CE showed the expression of the 80 new proteins and inhibition of 104 pro-teins. Discussion &

After the remov-al of common proteins between the two groups، those proteins that were affected by the extract assigned as drug targets for the treatment of Alzheimer. Changes at the molecular level were revealed with multi-variate statistical analyzes such as principal component analysis or correlation analysis and the clustering of proteins showed that the expression changes have been occurred in three main clusters. Finally، it could be concluded that lavender extract caused significant expression changes in the pro-teome and possibly activated specific biological processes in the rats’ hippoc-ampus that associated with enhancement of learning and memory in normal and Alzh-eimeric rats.

In order to planning and promoting the position in research field، we need to monitor the scientific production trend. This study aimed to assess the scientific productions of Paramedical Sciences School of Shahid Beheshti University of Medical Sciences in Scopus and ISI databases during 2009 to mid-2012.

Through a descriptive study، all the faculty members of Paramedical School were assessed in terms of scientific productions and H-index in Scopus and ISI databases from 2009 to mid-2012. Data were analyzed and presented as the number of total articles and citations during 3. 5 years ago separating by year and the H-indices in Scopus and ISI databases. Total articles were compared between the educational depart-ments using analysis of variance.

Means (Standard Deviation) of total articles in Scopus during 2009-2011 were as 0. 4 (0. 9)، 0. 6 (1. 3) and 0. 7 (1. 6) per faculty member، respectively. This figures were as 0. 2 (1)، 0. 4 (1. 2) and 0. 5 (1. 2) in ISI database. Mean of H-index in Scopus were 0. 9 (1. 5) and in ISI was 0. 7 (1. 3). Total articles of the departments had no statistically significant difference. Discussion &

Scientific prod-uctions and citations had an increasing trend in Scopus and ISI during the last 3 years but were less than the average of university.

Most of the traffic accidents are caused due to high speed. To decelerate vehicles traffic speed in the streets of the city of Kashan، a number of road bumps were made at defined intervals. This study was designed to study the effect of the road bumps on the incidence of traffic accidents.

This study was performed as a semi-empirical survey (before and after). The statistics of traffic accidents and their characteristics were recorded one month before the installation of the road bumps and the average calculated on a daily basis. Then، the statistics of traffic accidents and their characteristics were recorded one month after the installation of the road bumps. The mentioned statistics compared with each other and with the previous year.

This study indicated that the daily average number of casualties caused by traffic accidents and referred to hospitals was decreased in the first month of the plan in the streets of the city of Kashan، compared to previous month (p<0. 001). In the first month of the plan، serious injuries (fractures and lacerations) decreased compared to the previous month (p<0. 001). Discussion &

This research is one of the few studies that evaluated the effects of an intervention on the problems of traffic from the view point of health. The results indicated that execution of the program decreased the number of traffic accidents and created changes in the pattern of injuries and decreased the incidence of major injuries.