Effect of Phoenix Dactylifera Spathe Hydroalcoholic Extract on Chronic Pain in Mice

In Persian traditional medicine, many medicinal plants have been used as analgesics; in which one of them is the distillate of Phoenix Dactylifera Spathe (PDS) known as "Tarooneh". This study was conducted to assess the antinociceptive effect of Tarooneh (PDS) hydro alcoholic extract on inflammatory pain induced by formaline in mice. In this study, 28 male albio mice weighting 25 - 30 grams, were randomly and equally divided into 4 groups. 2, 20 and 200 mg/kg PDS extract and vehicle were administered intraperitomeally to the test and control groups respectively in a volume of 10 ml/kg. Animals were subjected to Formalin test as an animal model for inflammatory pain assessment. Mean pain score induced by formalin test in control group was 1.665 ± 0.0599 while in test groups receiving 2, 20 and 200 mg/kg PDS extract were 1.079 ± 0.0666, 0.9192 ± 0.0822 and 0.3842 ± 0.0658 respectively. data from this study revealed that PDS extract, significantly and dose dependently, attenuated the inflammatory formalin induced pain in mice.