Changes of Adipose Tissue Lipocalin-2 gene Expression in Response to One Session Exercise in the Streptozotocin-Induced Diabetic Rats

Lipocalin-2 has recently been identified as a novel adipokine, the concentration of which is positively associated with low grade inflammation, obesity, hyperglycemia and the metabolic syndrome. However, there is limited information available regarding the effect of exercise on Lipocalin-2 levels. The purpose of this study was to investigate the effect of one session exercise on adipose tissue Lipocalin-2 gene expression in diabetic rats. Twenty male Wister rats (160 ± 5 g) after diabetic induction were randomly divided into four groups, three exercise and one control. The training groups performed one exercise session on a motor-driven treadmill (45 min, 20 m/min). Animals in each groups were anesthetized immediately, 4h and 24h after exercise, respectively, and sampling was performed to assess adipose tissue Lipocalin-2 a gene expression, liver glycogen concentration, and plasma glucose and lipid profile levels. Adipose tissue Lipocalin-2 gene expression decreased 4h and 24h after exercise, whereas plasma HDL and Non-Esterified Fatty Acid levels increased and liver glycogen decreased immediately after exercise. The decline of Lipocalin-2 gene expression after exercise may be an indication of the anti-inflammatory effect of exercise in diabetic rats. However further research is necessary in order to understand the mechanisms involved mechanisms.