Lack of Association between Catalase Gene C-262T Polymorphism and Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease with unknown etiology which affects different organs. Evidences show that SLE patients have a defect in the scavenging of oxidative stress products. One of the effective defense systems against oxidative stress damages is catalase. This study was conducted to investigate the relationship between C-262T polymorphism of catalase gene and systemic lupus erythematosus. This case-control study was conducted on 107 patients with SLE and 140 healthy individuals matched by age, sex and ethnicity. PCR-RFLP method was used to identify C-262T polymorphism of catalase gene. Frequency of alleles and genotypes in patients and control group was statistically analyzed using χ 2 test. Frequency of CC, CT and TT genotypes of catalase gene were 77.6, 20.5 and 1.9 percent in SLE patients and 71.8, 27.5 and 0.7 percent in control group respectively, which was not significant. This study showed that C-262T polymorphism of catalase gene is not associated with SLE.