Effect of omega-3 supplementation on hyperactivity, oxidative stress in children with attention-deficit-hyperactivity disorder

Attention-deficit/hyperactivity disorder (ADHD) affect ~ 5% of school – aged children. This condition is associated commonly with difficulties in learning،behaviore، and psychosocial adjustment that persist into adulthood. Mounting evidence suggests that a lack of certain polyunsaturated fatty and stress oxidatie may contribute to neurodevelopmental and psychiatric disorders such as ADHD. In this clinical trial study، 100، 6-12 years old، children with ADHD under effective maitenance therapy were assingned randomly، in a double-blind-fashion، to receive Omega-3 fatty acids (635 mg Eicosapentaenoic acid (EPA)، 195mg Docosahexaenoic acid (DHA)) or placebo for 8 weeks. Outcome variables included activity of enzyme gelotatiun redoctase (GR)، catalase (CAT) and superoxid dismutase (SOD) and abbreviated conners 10-item parent rating scale (CPRS)، before and after supplementation. After 8 weeks supplementation a significant difference was observed in activity of SOD، GR enzymes (P)