Prophylactic Effect of Vitamin C on Cyclosporine A-induced Liver Toxicity
Author(s):
Abstract:
Background
Cyclosporine A (CsA) is an important immunosuppressive agent; however, its clinical use is limited by several side effects such as hepatotoxicity. Vitamin C (ascorbic acid) is a very important and powerful antioxidant and protects membranes against oxidation.Objectives
The aim of this study was to study protective role of vitamin C against CSA-induced hepatotoxicity.Materials And Methods
Thirty male Wister strain rats weighting 230-260g were randomly divided into 3 groups (n = 10): group A was the control group and received placebo (Normal Saline), group B was the CSA-treated group and received 15mg/kg/day CsA for 21 days, group C was the CsA + vitamin C group and was received 200mg/kg/day vitamin C orally 3 hours before receiving 15mg/kg/day CsA. On 22th day rats serum obtained for measuring biochemical factors including bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride, alkaline phosphatase (ALP) and lactate dehydrogenase (LDH), total protein, and albumin.Results
Bilirubin, ALT, AST, triglyceride, ALP, and LDH levels were lower in CsA + ascorbic acid group than that of CsA group (P < 0.05) while plasma total protein and albumin were significantly higher in CsA + ascorbic acid group than that of CsA group (P < 0.05).Keywords:
Language:
English
Published:
Thrita, Volume:1 Issue: 1, Sep 2012
Pages:
24 to 26
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