Preemptive pregabalin versus placebo for acute postoperative pain after total abdominal hysterectomy

Although pregabalin is primarily an anticonvulsive drug and is also ffective on chronic neuropathic pain، there are limited data regarding its effect on acute pain. In this study we assessed the analgesic effect of pregabalin on acute post operative pain used as preemptive analgesia in comparison to placebo and compared pain intensity and opium requirements among placebo and pregabalin group. Methods and materials: 60 females who scheduled for TAH in Rasoul -Akram hospital were chosen، aged between 30-70، and weighted between 60 - 80 kg. Thirty had taken oral pregabalin (300) mg one hour pre surgical procedure، the others received placebo. Pain level and doses of opioid substance were compared between two groups at 4، 8، 12، 16، 20 and 24 hours after surgery. Agitation status، nausea، vomiting and dizziness were also recorded and compared. Pain level at 12، 20، 24 hours were significantly lower in the pregabalin group. Meperidin needed dosage and agitation level was reduced in the pregabalin group (p < 0. 0001). Nausea and vomiting had no difference between two groups. Dizziness was higher in pregabalin group (p = 0. 03). Pregabalin as a preemptive drug before surgery can reduce postoperative pain and agitation. However can increase some complications like dizziness.