The Role of probiotics in the treatment and prevention of H.pylori Infection

Helicobacter pylori is a gram negative، motile، nonspore-producing rod that is inactive in many biochemical tests. The bacteria cannot fermentate or oxidate glucose but produce different enzymes like urease and catalase. This bacterium has been studied since 1893 by many scientists including Bizzozero. H. pylori is now recognized to be strongly related to peptic ulcer disease. Various virulence factors such as helical shape، adhesion factors، and urease enzyme are identified. Diagnosis is made by different methods like culture، histopathology، urease test and serology. Treatment includes variou single and multi drug regimens. The role of probiotics in prevention and treatment has recently gain attention.