Comparison of CD59 Concentration of Seminal Plasma of Fertile and Infertile Men

Cd59 is a complement control protein (CCP) wich exhibits its inhibitory functions by prevention of complement attack complex (MAX) formation. The aim of this normozoospermia, olig-astheno and azoospermia. The semen of 57 individual were grouped to normozoospermia (8), asthenozoospermia (21), oligo-astenozoospermia (16), and azoospermia (12) according to WHO ceriteria. After seperation of seminal plasma, the CD59 conccentration was measured by the sandwich ELAISA method, using two monoclonal antibody againts CD59. One as capture and the other for detection of CD59 protein. The mean concentration of CD59 within the Normozoospermia, asthenzoospermia, oligo-asthenozoospermia, and azoomospermia was: 33.53 ±4.26, 28.14±6.59, 20.32±7.43, reverse linear correlation between sperm density and CD59 concentration (r=-0.58, P=0.000). This is the first report, which shows differences in CD59 concentration between normal and abnormal semen samples. In this study we obtained a significant difference in the CD59 mean concentration of the normal group with both azoospermia and oligo-asthenozoospermia groups. As well as a negative correlation between CD59 concentration and sperm density and a positive correlation between CD59 concentration and sperm viability.