Frequency of H. pylori Infection in Dyspeptic Patients By Bacterial Antigen in Stool

One strategy in management of patient with dyspepsia in absence of malignant or ulcer signs is H.pylori infection role testing, and treatment of all positive cases. Because of high prevalence of pylori infection in Ardebil, and its probable role in chronic gastritis and dyspepsia as well as recently, FDA approved H.pylori stool antigen test for screening of suspicious patients, this study was design to evaluate the frequency of pylori infection in dyspepsia.

In this study, 100 dyspeptic patients of gastroenterology clinics of Ardebil city that had not responded to current therapies such as h2 blockers were entered study with excluding patients who taking antibiotics, proton pump inhibitors or Non Steroidal Anti inflammatory Drugs (NSAIDs) in last two weeks, and alarming danger signs such as weight loss, bleeding and melena. Stool antigen detection test for H.pylori were done for them.

100 patients enrolled in the study. The study group consists of 60 men and 40 women. The average age was 35 years (14-57 years).The prevalence of H. pylori was 72% among dyspeptic patient. Statistically significant differences were not seen between H.pylori infection and the sex, smoking, marriage and infection. There were no differences in clinical symptoms of dyspepsia among patients with and without H.pylori.

Among patients bothersome postprandial fullness was the most common symptom. Clinical signs were not useful in differentiate H.pylori infection persistence in dyspeptic patients. It seems that in hyper endemic areas for H.pylori such as Ardabil H.pylori has high association with dyspepsia, but for further explanation about its role in symptom creation, further population based studies With an emphasis on cost analysis and treatment outcome are needed.