The relationship between Umbilical cord Alpha Fetoprotein and Hyperbilirubinemia in Third day of birth

Hyperbilirubinemia is one of the most common diseases in neonatal period and the early diagnos of that is important to prevent complications. The aim of this study was to determine the relationship between umbilical cord alpha fetoprotein and hyperbilirubinemia in the third day of birth. In this descreptive cross-sectional study 120 neonates were entered in the study through random sampling، after the birth، blood samples of umbilical cord were collected. Serum Alpha-fetoprotein levels were measured by ELISA techniques. On the third day of the birth 1. 5CC were taken to determine the baby''s bilirubin level. Laboratory values were recorded in the form and demographic data were completed in the questionnaire for collecting the data. The data were analyzed using software SPSS and Spearman test، t-test. The results showed average weight of neonatal 3048. 75± 356. 23 gram، average amount of alpha-fetoprotein were 70. 63± 14. 20µg /l and mean bilirubin amount of were 10. 21± 3. 37 mgdl. There was no significant correlation between the weight and the amount of alpha-fetoprotein (P>0. 05). But between weight and amount of bilirubin in the third day after the birth there was a significant inverse relationship (P<0. 05، r=-0. 28)، Significant direct relationship was found between bilirubin and Alpha-fetoprotein (P<0. 05، r=0. 15). This study shows a statiscal relationship between alphafetoprotein and bilirubin، so، with further studies in this field، finding strong correlation between alpha-fetoprotein cord and neonatal hyperbilirubinemia، the samples from the umbilical cord can be used in screening for neonatal hyperbilirubinemia and jaundice.