Synthesis of silica nano-structure and loading particular lanthanides on them to use in radiotherapy

In this study, Silica nanoparticles with the size of 50 to 80 nm with were synthesized using a Sol-gel method and different amounts of Lanthanum Nitrate hexahydrate formed during the reaction of the particles, was added to the material. To examine the ability of these Nanostructures in a controlled release of drug such as Lanthanide, SBF (Simulated Body Fluid) was prepared and the release of Lanthanide 10 minute intervals for 48 hours was investigated and released Lanthanide concentration was evaluated by ICP (Inductively Coupled Plasma). According to the results of ICP, loaded Lanthanide was not released from the silica network. Loaded Lanthanides in the mesoporous can be used in radiotherapy, especially in cases of liver cancer.