Comparing the Efficacy of Metoclopramide and Chlorpromazine with Meperidine in Treatment of Headache after Ocular Surgery

This study aimed to compare the efficacy of intravenous chlorperomazine and metoclopramide with meperidine in treatment of headache after ocular surgery. A randomized double-blind clinical-trial was undertaken at Feiz hospital affiliated to Isfahan University of Medical Sciences (Iran) with 102 patients with severe headache after ocular surgery. Patients were divided randomly in 3 groups (34 patients in each group); first group received 0. 1 mg/kg/dose intravenous metoclopramide repeated after 30 minutes as needed; second group received 0. 35 mg/kg/dose meperidine repeated after 30 minutes as needed; and third group received 0. 1 mg/kg/dose intravenous chlorperomazine repeated after 30 minutes as needed. Adequate pain relief was measure for each patient by Faces Pain Rating Scale (FPRS) every 15 minutes from up to 45 minute. The average pain relief over 45 minutes for metoclopramide was 4. 71 vs. 5. 82 for meperidineand and 3. 94 for chlorperomazine (P < 0. 001 for three comparisons). There were no severe or significant side effects with any of studied drugs. Both، Intravenous metoclopramide and chlorpromazine، are more effective than meperidine for the treatment of the severe headaches after ocular surgery. Comparing the effectiveness of these 3 agents appears to favor chlorpromazine in measures of headache relief and incidence of headache rebound.