The Comparison of Serum Vitamin D Level in Patients with Iron Deficiency Anemia and Minor Thalassemia

Of the most common hypochromic microcytic anemia are iron deficiency anemia and minor thalassemia، which are common in Iran and their differential diagnosis is extremely important. The level of 25-hydroxy vitamin D is the indication of vitamin D blood status. The aim of this study was to compare serum levels of vitamin D in people with minor thalassemia and iron deficiency anemia with healthy subjects in order to investigate the relationship between vitamin D deficiency and iron absorption. In this case-control study، 24 patients with minor thalassemia، 20 patients with iron deficiency anemia and 24 healthy individuals participated. Groups were matched for age and sex. Testing of Vitamin D level by ELISA، ferritin by quantitative luminescence method and HbA2 by column chromatography was carried out. The number of individuals with low level of vitamin D in iron deficiency group is 15 (75%)، in minor thalassemia group is 8 (33/3%) and in the control group 11 (45. 8%). In this study، the highest percentage of vitamin D deficiency is observed in cases with iron deficiency anemia. Because of association between vitamin D and anemia، iron and vitamin D supplementation is recommended to enrich the diet.