Rosiglitazone Inhibits HMC-1 Cell Migration and Adhesion Through a Peroxisome Proliferator-Activated Receptor Gamma-Dependent Mechanism

Mast cells play an important role in a variety of inflammatory diseases, particularly asthma and atopy. Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the large nuclear hormone receptor transcription factor superfamily, and has been recently implicated in the anti-inflammatory response.To investigate a possible role for PPARγ in human mast cells, we studied the effects of a PPARγ ligand, rosiglitazone (RG), on stem cell factor (SCF)-induced migration and fibronectin-induced adhesion in human mast cell-1(HMC-1) cells.It was found that HMC-1 cells expressed PPARγ mRNA. RG inhibited SCF-induced HMC-1 cell migration and fibronectin-induced HMC-1 cell adhesion, the selective PPARγ antagonist GW9662 prevented the inhibitory effect of RG on HMC-1 cells.In conclusion, RG inhibits the migration and adhesion of HMC-1 cells by a PPARγ-dependent mechanism.