Pattern Electroretinography in Glaucoma Suspects and Early Primary Open Angle Glaucoma

To explore retinal ganglion cell (RGC) dysfunction in glaucoma suspects and patients with early primary open angle glaucoma (POAG) using pattern electroretinography (PERG). Twenty glaucoma suspects (glaucomatous optic disc appearance), 15 early POAG (based on abnormal discs and abnormal visual fields) and 16 normal controls were enrolled. Transient PERG was recorded in response to 0.8° and 16° black andwhite checkerboard stimuli. Amplitude and peak time (latency) of the P50 and N95 components of the PERG response, and the ratio of N95 amplitude in response to 0.8° and 16° checks were measured. N95 peak time (latency) was significantly increased in both early manifest POAG and glaucoma suspects as compared to normal controls (P)