Effects of activation and inactivation of glucocorticoid receptors of basolateral amygdala on fear memory extinction in rats
Author(s):
Abstract:
Introduction
Glucocorticoid receptors (GRs) of basolateral amygdala (BLA) play an important role in emotional learning and memory. The aim of present study was to determine the role of GRs of BLA in extinction of fear memory in inhibitory avoidance learning (PAL) in rats. Materials And Methods
Rats with surgically implanted bilaterally cannulae aimed at the BLA were trained and tested in an inhibitory avoidance task. Animals received bilateral microinjections of corticosterone (CORT, 0.3 or 3ng/0.5µl per side), RU38486 (0.3 or 3 ng/10.5µl per side /side) or combinenation of both drugs into BLA 30 min before the first retrieval test which was done 2 days after training. Memory retention again tested 2, 9, 12, 14 and 16 days after the first retention test, during which the latency to re-enter dark compartment of the apparatus was recorded. Results
Results indicated that microinjections of both CORT and RU38486 and also their combination into BLA facilitated the extinction of fear memory. Conclusion
It seems that GRs located in the BLA nucleus play a critical role in fear memory extinction.Keywords:
Language:
Persian
Published:
Koomesh, Volume:15 Issue: 3, 2014
Pages:
405 to 411
magiran.com/p1244754
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!