Salivary total antioxidant capacity and lipid peroxidation in patients with erosive oral lichen planus

Oral lichen planus is a common chronic inflammatory disease in oral mucosa with malignant potential, pathogenesis of which is not still well known. Free radicals and reactive oxygen species can play an important role in the pathogenesis of oral lichen planus. The aim of this study was investigation of salivary oxidative stress and antioxidant systems patients with oral lichen planus. In this case-control study, 30 patients with oral lichen planus(case group) and 30 age- and gender-matched healthy subjects(control group) that referred to dental school of Babol University of Medical Sciences, were selected using simple sampling method. Unstimulated saliva of two groups was collected. Salivary total antioxidant capacity (TAC) and lipid peroxidation products were investigated and compared using ferric reducing antioxidant power (FRAP) and thiobarbituric acid reactive substance (TBARS) methods respectively. The data were analysed using T-student test. The mean and standard deviation of salivary TAC in patients with oral lichen planus (297.23±149.72μM) was significantly lower than the controls (791.43±183.95μM) (P)