Evaluation of methanol extracts activity of seed, skin, leaf and juice from five Iranian grape cultivars on lymphocyte proliferation

Abstract Vitis vinifera has a number of flavonoids which applied as antioxidant and anti-cancer activity. The present study was carried out to investigate effects of seed, skin, juice and leaf extracts of five grape species gathered from Qazvin and Kashan provinces on lymphocyte proliferation. This experimental study was done on grape species of Shahroodi, Bidane sefid, Halvaie, Yaghoti and Ghermez yaghoti drosht. The effect of different part of this grape cultivars on lymphocyte proliferation was measured by MTT assay at different concentrations (10, 100, 1000, 2000, 3000 μg/ml). The seeds and old leaves of all five grape cultivars had high activity on lymphocyte proliferation, but juice did not affect lymphocyte proliferation. It seems that different part of grape plant has proliferating effect on lymphocyte, so it may be helpful for treatment of some immunodeficiency diseases.