Methadone and valproate combination effect on acquisition and expression of morphine dependence and tolerance in male mice
Author(s):
Abstract:
Background And Objective
According to the issue of dependence and tolerance in addicted patients, the inefficiency of existing treatments and the new recommendation for drug combination therapy for diseases in modern pharmacology, the present study examined the effect of methadone and valproate combination on morphine dependence and tolerance. Materials And Methods
Ninety-eight male mice were divided into the following groups: saline, morphine, methadone, valproate, and three groups of valproate+methadone, i.e. 1 to 1, 2 to 1 and 1 to 2 ratios. Except for the saline group, the others received escalating dose of morphine for 8 consecutive days. In acquisition group, drugs were injected for 30 minutes before morphine administration. In expression group, the drugs were used only at 8th day (test day). Morphine tolerance was measured by tail immersion test and for dependence assessment, naloxone-induced withdrawal signs was evaluated. Results
Jumping behavior as a main sign of dependence in both acquisition and expression significantly reduced in methadone1+valproate2 treatment group. Also, acquisition and expression of tolerance significantly decreased in valproate and methadone1+valproate2 more than other groups. Conclusion
Our results show that methadone and valproate combination treatment could probably reduce tolerance and dependence more than single valproate or methadone treatments.Keywords:
Dependence , Tolerance , Morphine , Methadone , Valproate
Language:
English
Published:
Journal of Basic & Clinical Pathophysiology, Volume:2 Issue: 1, Winter-Spring 2014
Pages:
15 to 22
magiran.com/p1260883
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!