Dengue-associated kidney disease

Context: A mosquito-borne viral illness highly prevalent in the tropics and subtropics, dengueis considered a major global health threat by the World Health Organization.Evidence Acquisitions: Directory of Open Access Journals (DOAJ), Google Scholar, PubMed(NLM), LISTA (EBSCO) and Web of Science have been searched. An RNA virus from the genus Flavivirus, dengue virus is transmitted by Aedes aegypti,the yellow fever mosquito. Dengue is asymptomatic in as many as one half of infectedindividuals. Dengue fever is an acute febrile illness accompanied by constitutional symptoms.Dengue hemorrhagic fever and dengue shock syndrome are the severe forms of dengue infection.Dengue infection has been associated with a variety of renal disorders. Acute renalfailure is a potential complication of severe dengue infection and is typically associated withhypotension, rhabdomyolysis, or hemolysis. Acute renal failure complicates severe dengueinfection in 2-5% of the cases and carries a high mortality rate. Proteinuria has been detectedin as high as 74% of patients with severe dengue infection. Hematuria has been reported inup to 12.5% of patients. Various types of glomerulonephritis have been reported during orshortly after dengue infection in humans and mouse models of dengue infection. Mesangialproliferation and immune complex deposition are the dominant histologic features of dengue-associated glomerulonephritis. On a rare occasion, dengue infection is associated withsystemic autoimmune disorders involving the kidneys. In the vast majority of cases, dengue infection and associated renal disorders areself-limited.