Evaluation of urinary enzymes in newborns treated with gentamicin
Author(s):
Abstract:
Objective(s)
In recent years, there has been an increasing amount of study on early diagnosis of kidney injury through sensitive and specific biomarkers. We examined the practical applicability of the urinary levels of NAG (N-acetyl-β-D-glucosaminidase), AP (alkaline phosphatase), and LDH (lactate dehydrogenase) as renal dysfunction screening biomarkers in full and pre-term newborns treated with gentamicin. Materials And Methods
Fourteen pre-term and fifteen full-term newborns who received gentamicin for suspected infections were enrolled. Serum and urine specimens were obtained before the zero days and after gentamicin infusion on the 1st, 3rd, and 5th days of treatment. Results
In full-term newborns a significant increase in urinary NAG, LDH, AP after 5 days of gentamicin administration compared with control group was noted (P<0.05, PP<0.01; respectively). Conclusion
Our findings indicate that urinary enzymes may be useful in full-term newborns as a non-invasive method for evaluation of tubular function.Keywords:
Biomarker , Gentamicin , Newborn , Urine
Language:
English
Published:
Iranian Journal of Basic Medical Sciences, Volume:17 Issue: 5, May 2014
Pages:
384 to 388
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