The Survey of Serum Trace Element Profiles in Down's Syndrome

Immunological, endocrinological, haematological and neurological abnormalities are relatively common in people with Down''s syndrome (DS). Zinc (Zn), copper (Cu), selenium (Se) and manganese (Mn) are elements that act in the maintenance of normal function of these systems. The present study aimed to evaluate the concentration of these elements on DS symptoms. This case-control study was done from April to October 2011. Serum trace elements including Zn, Cu, Se and Mn were determined by using atomic absorption spectrometry (AAS) in 56 patients with DS and 60 healthy subjects. There was no significant difference in the values of Cu and Se between two groups (p>0.05). While, Zn and Mn levels were found to be significantly decreased in patients with DS compared to the control group (p<0.01 and p<0.001, respectively). Results of this study indicate zinc and manganese deficiency in more than 60% of DS patients. Some of the problems experienced by people with DS may be due to changed level of these trace elements.