Detection of urine interleukin-8 levels as a noninvasive method for diagnosis of vesicoureteral reflux in children after resolvent urinary tract infection

The retrograde flow of urine from the bladder to the ureter (Vesicoureteral Reflux -VUR) is a common finding in children with Urinary Tract Infection (UTI) that can result in renal injury. Diagnosis of reflux requires interventional invasive imaging (Voiding Cystourethrogram -VCUG). Detection of urine Interleukin-8 (IL8) levels as a noninvasive method can be usefull method for diagnosis of VUR in children after resolvent UTI. In this cross sectional study, 80 children in whom at least one month had passed from their UTI treatment were assessd. According to VCUG, the children were divided in to two groups; “case group” consisted of 40 patients with VUR and “control group” consisted of 40 patients without VUR. Then urinary levels of IL8 and creatinin were assassed. T_study and chi square were used for analytical conclusions in SPSS software. From 80 children, 12 were males and 68 were females. Overall mean age was 32-48 months. From 40 VUR patients, 22 had unilateral reflux. Relation of IL8 to Ucr in the first group (VUR positive) was 4.9±7.60 pg/µmol and in the second group was 5.2±9.46 pg/µmol revealing no significant relationship between the two groups. Also there was any relationship between IL8/Ucr in different grades of reflux, uni/ bilateral cases and infant age with older. Urinary IL8 is not a benefit marker for screening, diagnosis and follow up of patients with VUR.