Insulin Infusion on Postoperative Complications of Coronary Artery Bypass Graft in Patients With Diabetes Mellitus

Cardiovascular events are common in patients with diabetes mellitus (DM), which make coronary artery bypass graft (CABG) a highly demanded surgery in this population. Tight control of blood glucose in patients with DMis beneficial in reducing postoperative complications; however, the adequate range has not been determinedyet.. This study aimed to investigate the effect of semi-tight (moderate) control of DMon complications and serum glucose levels during and after CABG..Patients and In this prospective clinical trial, 18 and 31 patients with and without DM, respectively, who were referred to Shahid Chamran Hospital, Isfahan, Iran, for elective CABG surgery, were enrolled. For DM group, patients with controlled DM (i.e. glycosylated hemoglobin levels [HgA1C] ≤ 7%) were recruited. Blood glucose level (BS) was measured after anesthesia, during pumping, warming, offpumping, six and 12 hours after ICU admission, and at discharging from the hospital. The hemodynamic state of the patients, bleeding, need of blood transfusion, infection, and duration of hospitalization were also monitored and recorded.. None of the BS measurements (FBS, after anesthesia, on-pump, warming, offpump, six and 12 hours after ICU admission, and at discharge) were significantly different between study groups (P > 0.05). Prevalence of surgery site bleeding and blood transfusion need were not significantly different between these groups (P > 0.05).. Semi-tight control of DM with insulin infusion during operation did not led to any difference in the type and rate of CABG complications between patients with well-controlled and those without DM; however, BS levels in patients with well-controlled DM could be more easily controlled..