Determination and Comparison of Estimated Menopausal Age Based on Serum Anti-Mullerian Hormone in Women with and without Polycystic Ovarian Syndrome

Menopause is defined as 12 months of constant amenorrhea in the absence of any pathology. Right now there is no definite test to predict menopause age and the ovarian reserve evaluations are mainly implemented on the basis of sonographic and hormonal measurements. The present study was conducted to determine and compare the menopausal age in women with polycystic ovarian syndrome (PCOS) and non PCOS women based on anti-mullerian hormone (AMH). The present study is an epidemiologic case- control research in which from among 1019 women aged 20-40years، 208 PCOS women and 811 normo-ovulatory controls were selected as the case and control groups respectively. Data collection was done through completing questionnaire، clinical examination and lab test measurements. After age and body mass index (BMI) matching، AMH levels in relation to age were displayed in an interactive graph and SPSS software version 21 was used for statistical analysis. Findings showed the mean age and BMI for case and control groups were 29. 75 years – 27. 1 (kg/m2) and 31. 62 years – 26. 1 (Kg/m2) respectively. Our results indicated significantly higher AMH levels in PCOS cases than in normal controls (P<0. 0001). The estimated menopausal age for PCOS and non PCOS women was 51 and 49 years respectively. To conclude PCOS patients reach menopause two years later than healthy women. If the length of reproductive period in these patients is higher than that the healthy women، it may be possible to use this period for increasing the fertility likelihood.