New diagnostic criteria for multiple sclerosis in patients with clinically isolated syndromes: Some questions could be raised during clinical practice

During the past decades, several diagnostic criteria for multiple sclerosis (MS) have been developed and used according to demonstration of lesions disseminated in space and time. The European Multicenter Collaborative Research Network on MRI in MS (MAGNIMS) suggested very interesting and helpful diagnostic criteria for MS in 2010. We believe that these criteria are beneficial since they enhance the way practitioners and researchers deal with clinically isolated syndromes and accelerate their decision making. However, some questions will still remain to be answered in this regard. We think that the addressed challenging points are needed to be remarked in the final guideline to prevent potential misunderstanding in both routine clinical practice and research field.